About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe
targeted mutation 8, Scott Lowe
MGI:4999898
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae 		involves: 129S4/SvJae * C57BL/6 MGI:5000007
cx2
 		Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+
Tg(CMV-rtTA)4Bjd/0 		involves: 129S4/SvJae * C57BL/6 * NMRI MGI:5000005
cx3
 		Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Tg(CMV-rtTA)4Bjd/0 		involves: 129S4/SvJae * C57BL/6 * NMRI MGI:5000006


Genotype
MGI:5000007
cx1
Allelic
Composition		 Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe mutation (0 available); any Col1a1 mutation (163 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (992 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:171348 )
• most mice treated with doxycycline between 5 and 10 weeks of age die prematurely

growth/size/body
weight loss ( J:171348 )
• in doxycycline-treated mice

cellular
abnormal cell cycle ( J:171348 )
• doxycycline-treated mice exhibit cell cycle arrest unlike control mice




Genotype
MGI:5000005
cx2
Allelic
Composition		 Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+
Tg(CMV-rtTA)4Bjd/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe mutation (0 available); any Col1a1 mutation (163 available)
Tg(CMV-rtTA)4Bjd mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:171348 )
• most mice treated with doxycycline between 5 and 10 weeks of age die prematurely

growth/size/body
weight loss ( J:171348 )
• in doxycycline-treated mice

cellular
abnormal cell cycle ( J:171348 )
• doxycycline-treated mice exhibit cell cycle arrest in the liver, spleen, and intestine unlike control mice




Genotype
MGI:5000006
cx3
Allelic
Composition		 Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1+
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Tg(CMV-rtTA)4Bjd/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm8(tetO-GFP/RNAi:Rpa3)Slowe mutation (0 available); any Col1a1 mutation (163 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (30 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(CMV-rtTA)4Bjd mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:171348 )
• half of mice treated with doxycycline between 5 and 10 weeks of age die prematurely

growth/size/body
weight loss ( J:171348 )
• in doxycycline-treated mice

cellular
abnormal cell cycle ( J:171348 )
• doxycycline-treated mice exhibit cell cycle arrest in the liver, spleen, and intestine unlike control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory