Analysis Tools
skeleton
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• in mice with severe hair loss
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• mice with severe hair loss also show incisor abnormalities including absence of a lower incisor and overextending or shortening of one lower incisor
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integument
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• at P24 and 6 months of age
• increase in the number of sebaceous glands at 5 months of age
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• enlarged skin sebaceous glands at P24 and 6 months of age
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• all pups born with hair show increased hair loss with age
• completely alopecic at 5 months of age
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• mice with gross alopecia at P5 show hair follicle abnormalities
• the least affected mice show striking defects in hair follicle morphology at P24 (telogen phase) and P32 (anagen phase) but only slight defects at earlier times
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• at 5 months of age remaining hair follicles are dilated forming large cysts containing keratinaceous debris
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• expression analysis indicates hair differentiation is disrupted when the hair cycle is deregulated
• increase in proliferation in the remaining hair follicles that had not completely disintegrated into cysts at 5 months of age
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• in the least affected mice at P17 some follicles are delayed in their entry into catagen phase
• at P32 in the least affected mice the hair cycle appears completely deregulated
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• in the least affected mice at P24 hair follicles remain in catagen rather than starting to enter anagen as in controls
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• at 5 months of age remaining hair follicles are dilated forming large cysts containing keratinaceous debris
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• at 5 months of age the skin has 3-5 more basal layers of epithelial cells compared to the skin of littermate controls
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• at 5 months of age
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• increase in proliferation in the basal layer of the epidermis at 5 months of age but not from P11 to P32
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growth/size/body
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• in mice with severe hair loss
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• mice with severe hair loss also show incisor abnormalities including absence of a lower incisor and overextending or shortening of one lower incisor
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• at 5 months of age remaining hair follicles are dilated forming large cysts containing keratinaceous debris
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• stunted growth by P5
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craniofacial
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• in mice with severe hair loss
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• mice with severe hair loss also show incisor abnormalities including absence of a lower incisor and overextending or shortening of one lower incisor
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reproductive system
| N |
• despite cre expression in the mammary gland females are fertile and able to nurse pups
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digestive/alimentary system
| N |
• despite cre expression in the tongue and esophagus no gross abnormalities are detected in these tissues
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endocrine/exocrine glands
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• at P24 and 6 months of age
• increase in the number of sebaceous glands at 5 months of age
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• enlarged skin sebaceous glands at P24 and 6 months of age
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