Phenotypes associated with this allele

• Allele Symbol: Tg(Alb-TAg)#Arnd
• Allele Name: transgene insertion, Bernd Arnold
• Allele ID: MGI:5000250
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Alb-TAg)#Arnd/0	C3Fe.Cg-Tg(Alb-TAg)#Arnd	MGI:5000253
tg2	Tg(Alb-TAg)#Arnd/0	(C3Fe.Cg-Tg(Alb-TAg)#Arnd x C57BL/6N)F1	MGI:5000254

Genotype
MGI:5000253

cn1

• Allelic Composition: Tg(Alb-TAg)#Arnd/0
• Genetic Background: C3Fe.Cg-Tg(Alb-TAg)#Arnd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:171880 )

• mice treated with an adenovirus expressing cre exhibit massive multinodular hepatocellular carcinomas unlike control mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:171880 )

• mice treated with an adenovirus expressing cre exhibit massive multinodular hepatocellular carcinomas unlike control mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:171880

Genotype
MGI:5000254

tg2

• Allelic Composition: Tg(Alb-TAg)#Arnd/0
• Genetic Background: (C3Fe.Cg-Tg(Alb-TAg)#Arnd x C57BL/6N)F1

immune system

abnormal immune system physiology ( J:171880 )

• mice treated with an adenovirus expressing cre are tolerant to SV40 T antigen unlike control mice

• however, immunization with the agonistic peptide IVc-l breaks tolerance