Phenotypes associated with this allele

• Allele Symbol: Tg(AR*100Q)C25Als
• Allele Name: transgene insertion C25, Albert La Spada
• Allele ID: MGI:5000265
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(AR*100Q)C25Als/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5000279

Genotype
MGI:5000279

tg1

• Allelic Composition: Tg(AR*100Q)C25Als/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:89772 )

• mice die of unknown causes at 15 to 22 months of age

behavior/neurological

ataxia ( J:89772 )

• at 14 months, mice exhibit impaired mobility and difficulty walking compared with control mice

impaired coordination ( J:89772 )

• at 11 months, mice exhibit decreased latency to fall on a wire hanging test compared with control mice

abnormal gait ( J:89772 )

• at 13 months, male mice exhibit impaired gait compared with control mice

• at 26 months, female mice exhibit impaired gait compared with control mice

short stride length ( J:89772 )

• at 11 months

hindlimb paralysis ( J:89772 )

• at 17 months, male mice exhibit hindlimb paralysis unlike control mice

• however, female mice do not exhibit severe hindlimb paralysis

muscle

abnormal muscle morphology ( J:89772 )

• mice exhibit nuclear inclusions in the liver and muscle unlike in control mice

skeletal muscle atrophy ( J:89772 )

• at 13 months, male mice exhibit hindlimb atrophy unlike control mice

• at 17 months, male mice exhibit severe hindlimb atrophy unlike control mice

• at 26 months, female mice exhibit hindlimb atrophy unlike control mice

• however, female mice do not exhibit severe hindlimb atrophy

muscle weakness ( J:89772 )

• mice exhibit proximal muscle weakness that accompanies weight loss unlike control mice

growth/size/body

decreased body size ( J:89772 )

• beginning at 8 months of age in male mice and 17 months of age in female mice

decreased body weight ( J:89772 )

• beginning at 8 months of age in male mice and 17 months of age in female mice

postnatal growth retardation ( J:89772 )

• at 8 months of age

nervous system

motor neuron degeneration ( J:89772 )

• at 14 months

liver/biliary system

abnormal liver morphology ( J:89772 )

• mice exhibit nuclear inclusions in the liver and muscle unlike in control mice

skeleton

kyphosis ( J:89772 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kennedy's disease		DOID:0060161	OMIM:313200	J:89772