Phenotypes associated with this allele

• Allele Symbol: Trib1^tm1Aki
• Allele Name: targeted mutation 1, Shizuo Akira
• Allele ID: MGI:5000311
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trib1^tm1Aki/Trib1^tm1Aki	involves: 129P2/OlaHsd	MGI:5000312

Genotype
MGI:5000312

hm1

• Allelic Composition: Trib1^tm1Aki/Trib1^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased eosinophil cell number ( J:196449 )

increased neutrophil cell number ( J:196449 )

• in the spleen

• slightly increased Gr-1^high neutrophils

decreased macrophage cell number ( J:196449 )

• absence of red pulp macrophages

• severely decreased tissue-resident macrophages

• severely decreased numbers of F4/80+Mac1+ cells in the blood and bone marrow

• severely decreased MR+F4/80+ adipose-tissue-resident M2-like macrophages in stromal vascular fraction derived from epididymal adipose tissue

• however, splenic metallophilic, marginal zone macrophages and peritoneal resident macrophages are normal

decreased spleen iron level ( J:196449 )

abnormal spleen red pulp morphology ( J:196449 )

• absence of red pulp macrophages

• however, splenic metallophilic and marginal zone macrophages are normal

decreased interleukin-12 secretion ( J:126085 )

• macrophage stimulated with LPS, MALP-2, or CpG DNA in the presence of IFN-gamma produce less IL12-p40 compared with similarly treated wild-type cells

homeostasis/metabolism

decreased spleen iron level ( J:196449 )

impaired glucose tolerance ( J:196449 )

• in mice fed a high fat diet

insulin resistance ( J:196449 )

• in mice fed a high fat diet

increased liver iron level ( J:196449 )

adipose tissue

decreased white fat cell size ( J:196449 )

• however, reconstitution with wild-type M2-like macrophages rescues lipodystrophy

abnormal epididymal fat pad morphology ( J:196449 )

• smaller

• however, reconstitution with wild-type M2-like macrophages restores adipose tissue size

lipodystrophy ( J:196449 )

• however, reconstitution with wild-type M2-like macrophages rescues lipodystrophy

growth/size/body

decreased body weight ( J:126085 )

• until 2 to 3 weeks of age

postnatal growth retardation ( J:126085 )

• slight until 2 to 3 weeks of age

liver/biliary system

increased liver iron level ( J:196449 )

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:196449 )

decreased eosinophil cell number ( J:196449 )

increased neutrophil cell number ( J:196449 )

• in the spleen

• slightly increased Gr-1^high neutrophils

decreased macrophage cell number ( J:196449 )

• absence of red pulp macrophages

• severely decreased tissue-resident macrophages

• severely decreased numbers of F4/80+Mac1+ cells in the blood and bone marrow

• severely decreased MR+F4/80+ adipose-tissue-resident M2-like macrophages in stromal vascular fraction derived from epididymal adipose tissue

• however, splenic metallophilic, marginal zone macrophages and peritoneal resident macrophages are normal

decreased spleen iron level ( J:196449 )

abnormal spleen red pulp morphology ( J:196449 )

• absence of red pulp macrophages

• however, splenic metallophilic and marginal zone macrophages are normal