Phenotypes associated with this allele

• Allele Symbol: Tg(Gfap-gp120)#Lms
• Allele Name: transgene insertion, Lennart Mucke
• Allele ID: MGI:5000435
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Gfap-gp120)#Lms/0	involves: C57BL/6 * SJL	MGI:5881828

Genotype
MGI:5881828

tg1

• Allelic Composition: Tg(Gfap-gp120)#Lms/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased neuronal precursor proliferation ( J:170738 )

• 40% reduction of BrdU+ cells in the dentate gyrus, indicating decreased proliferation of hippocampal neural progenitor cells

• 50% decrease in proliferating amplifying neural progenitor cells (BrdU+Sox2+GFAP-) in the hippocampus

• however, numbers of proliferating quiescent neural progenitor cells are normal

• a 10 day period of voluntary running completely rescues the deficit in neural progenitor cell proliferation in the dentate gyrus, and the deficit in amplifying neural progenitor cell proliferation and total numbers

• paroxetine treatment for 30 days leads to rescue of hippocampal neural progenitor cell and amplifying neural progenitor cell proliferation

abnormal dentate gyrus morphology ( J:170738 )

• 45% and 55% reduction in the number of newly generated mature neurons and immature neurons in the dentate gyrus

abnormal nervous system development ( J:170738 )

• 45% and 55% reduction in the number of newly generated mature neurons and immature neurons in the dentate gyrus

• however, no differences in cell fate specification of hippocampal neural progenitor cells are seen

• reduction in adult hippocampal neurogenesis results mainly from decreased proliferation rather than impairment of neuronal fate specification or survival of newly generated neurons

• exercise rescues adult hippocampal neurogenesis defects by increasing generation of newly born neurons

• paroxetine treatment rescues adult hippocampal neurogenesis

abnormal dendrite morphology ( J:170738 )

• initial dendritic development of newly generated adult hippocampal neurons is accelerated with mice showing elaborate dendritic trees in individual neurons, with increased dendritic length, increased dendritic branch number, and greater dendritic complexity in neurons

• voluntary exercise normalizes the aberrant initial dendritic development

decreased neuronal precursor cell number ( J:170738 )

• 60% reduction in total numbers of amplifying neural progenitor cells

cellular

decreased neuronal precursor proliferation ( J:170738 )

• 40% reduction of BrdU+ cells in the dentate gyrus, indicating decreased proliferation of hippocampal neural progenitor cells

• 50% decrease in proliferating amplifying neural progenitor cells (BrdU+Sox2+GFAP-) in the hippocampus

• however, numbers of proliferating quiescent neural progenitor cells are normal

• a 10 day period of voluntary running completely rescues the deficit in neural progenitor cell proliferation in the dentate gyrus, and the deficit in amplifying neural progenitor cell proliferation and total numbers

• paroxetine treatment for 30 days leads to rescue of hippocampal neural progenitor cell and amplifying neural progenitor cell proliferation