Phenotypes associated with this allele

• Allele Symbol: Oprm1^tm1Shlz
• Allele Name: targeted mutation 1, Stefan Schulz
• Allele ID: MGI:5000465
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprm1^tm1Shlz/Oprm1^tm1Shlz	involves: C57BL/6	MGI:5295049

Genotype
MGI:5295049

hm1

• Allelic Composition: Oprm1^tm1Shlz/Oprm1^tm1Shlz
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to morphine ( J:176122 )

• mice treated with morphine exhibit greater dose-dependent antinociceptive response compared with similarly treated wild-type mice

• however, acute morphine tolerance is retained

abnormal chemically-elicited antinociception ( J:176122 )

• antinociception tolerance to etonitazene is reduced compared to in wild-type mice

• DAMGO-treated mice fail to develop antinociception tolerance unlike similarly treated wild-type mice

• however, tolerance to morphine is normal

increased chemically-elicited antinociception ( J:176122 )

• in mice treated with morphine or fentanyl