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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stab1tm1.1Cger
targeted mutation 1.1 Cyrill Geraud
MGI:5000470
Summary 4 genotypes


Genotype
MGI:5000483
hm1
Allelic
Composition		 Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic
Background		 B6.129S2-Stab1tm1.1Cger
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stab1tm1.1Cger mutation (0 available); any Stab1 mutation (124 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:171818 )
• mice exhibit no physical or behavioral abnormalities




Genotype
MGI:5000484
hm2
Allelic
Composition		 Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic
Background		 C.129S2-Stab1tm1.1Cger
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stab1tm1.1Cger mutation (0 available); any Stab1 mutation (124 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:171818 )
• mice exhibit no physical or behavioral abnormalities




Genotype
MGI:5000485
cx3
Allelic
Composition		 Stab1tm1.1Cger/Stab1tm1.1Cger
Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic
Background		 B6.129S2-Stab2tm1.1Cger Stab1tm1.1Cger
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stab1tm1.1Cger mutation (0 available); any Stab1 mutation (124 available)
Stab2tm1.1Cger mutation (0 available); any Stab2 mutation (138 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Liver fibrosis in Stab1tm1.1Cger/Stab1tm1.1Cger Stab2tm1.1Cger/Stab2tm1.1Cger mice

mortality/aging
premature death ( J:171818 )
• mean survival is 415 days

renal/urinary system
albuminuria ( J:171818 )
• moderately elevated at 3 and 6 months
• highly elevated at 18 months
renal glomerulus fibrosis ( J:171818 )
• mice exhibit collagen deposits and glomerular fibrosis unlike wild-type mice
• however, fibrosis is rescued by transplanting kidney into wild-type mice
renal glomerulus hypertrophy ( J:171818 )
• at 18 months, renal glomeruli are enlarged compared to in wild-type mice
abnormal kidney physiology ( J:171818 )
• albuminuria suggests impaired glomerular filter function compared to in wild-type mice

liver/biliary system
liver fibrosis ( J:171818 )
• perisinusoidal
abnormal liver physiology ( J:171818 )
• hepatic blood clearance of hyaluronan and Gdf15 is impaired compared to in wild-type mice

homeostasis/metabolism
albuminuria ( J:171818 )
• moderately elevated at 3 and 6 months
• highly elevated at 18 months

cardiovascular system
cardiovascular system phenotype ( J:171818 )
N
• mice do not exhibit signs of cardiac disease




Genotype
MGI:5000486
cx4
Allelic
Composition		 Stab1tm1.1Cger/Stab1tm1.1Cger
Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic
Background		 C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stab1tm1.1Cger mutation (0 available); any Stab1 mutation (124 available)
Stab2tm1.1Cger mutation (0 available); any Stab2 mutation (138 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Mesangial expansion and glomerular fibrosis in Stab1tm1.1Cger/Stab1tm1.1CgerStab2tm1.1Cger/Stab2tm1.1Cger mice

mortality/aging
premature death ( J:171818 )
• mean survival is 269 days

cardiovascular system
dilated cardiomyopathy ( J:171818 )
• incipient to overt with or without heart failure and pulmonary congestion
congestive heart failure ( J:171818 )
• in some mice

renal/urinary system
albuminuria ( J:171818 )
• highly elevated at 3 and 6 months
renal glomerulus fibrosis ( J:171818 )
• mice exhibit collagen deposits and glomerular fibrosis unlike wild-type mice
• however, fibrosis is rescued by transplanting kidney into wild-type mice
abnormal kidney physiology ( J:171818 )
• albuminuria suggests impaired glomerular filter function compared to in wild-type mice

liver/biliary system
liver fibrosis ( J:171818 )
• perisinusoidal
abnormal liver physiology ( J:171818 )
• hepatic blood clearance of hyaluronan and Gdf15 is impaired compared to in wild-type mice

respiratory system

homeostasis/metabolism
albuminuria ( J:171818 )
• highly elevated at 3 and 6 months

muscle
dilated cardiomyopathy ( J:171818 )
• incipient to overt with or without heart failure and pulmonary congestion




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory