About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Stab1tm1.1Cger
targeted mutation 1.1 Cyrill Geraud
MGI:5000470
Summary 4 genotypes


Genotype
MGI:5000483
hm1
Allelic
Composition
Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic
Background
B6.129S2-Stab1tm1.1Cger
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stab1tm1.1Cger mutation (0 available); any Stab1 mutation (124 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice exhibit no physical or behavioral abnormalities




Genotype
MGI:5000484
hm2
Allelic
Composition
Stab1tm1.1Cger/Stab1tm1.1Cger
Genetic
Background
C.129S2-Stab1tm1.1Cger
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stab1tm1.1Cger mutation (0 available); any Stab1 mutation (124 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice exhibit no physical or behavioral abnormalities




Genotype
MGI:5000485
cx3
Allelic
Composition
Stab1tm1.1Cger/Stab1tm1.1Cger
Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic
Background
B6.129S2-Stab2tm1.1Cger Stab1tm1.1Cger
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stab1tm1.1Cger mutation (0 available); any Stab1 mutation (124 available)
Stab2tm1.1Cger mutation (0 available); any Stab2 mutation (138 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Liver fibrosis in Stab1tm1.1Cger/Stab1tm1.1Cger Stab2tm1.1Cger/Stab2tm1.1Cger mice

mortality/aging
• mean survival is 415 days

renal/urinary system
• moderately elevated at 3 and 6 months
• highly elevated at 18 months
• mice exhibit collagen deposits and glomerular fibrosis unlike wild-type mice
• however, fibrosis is rescued by transplanting kidney into wild-type mice
• at 18 months, renal glomeruli are enlarged compared to in wild-type mice
• albuminuria suggests impaired glomerular filter function compared to in wild-type mice

liver/biliary system
• perisinusoidal
• hepatic blood clearance of hyaluronan and Gdf15 is impaired compared to in wild-type mice

homeostasis/metabolism
• moderately elevated at 3 and 6 months
• highly elevated at 18 months

cardiovascular system
N
• mice do not exhibit signs of cardiac disease




Genotype
MGI:5000486
cx4
Allelic
Composition
Stab1tm1.1Cger/Stab1tm1.1Cger
Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic
Background
C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stab1tm1.1Cger mutation (0 available); any Stab1 mutation (124 available)
Stab2tm1.1Cger mutation (0 available); any Stab2 mutation (138 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mesangial expansion and glomerular fibrosis in Stab1tm1.1Cger/Stab1tm1.1CgerStab2tm1.1Cger/Stab2tm1.1Cger mice

mortality/aging
• mean survival is 269 days

cardiovascular system
• incipient to overt with or without heart failure and pulmonary congestion
• in some mice

renal/urinary system
• highly elevated at 3 and 6 months
• mice exhibit collagen deposits and glomerular fibrosis unlike wild-type mice
• however, fibrosis is rescued by transplanting kidney into wild-type mice
• albuminuria suggests impaired glomerular filter function compared to in wild-type mice

liver/biliary system
• perisinusoidal
• hepatic blood clearance of hyaluronan and Gdf15 is impaired compared to in wild-type mice

respiratory system

homeostasis/metabolism
• highly elevated at 3 and 6 months

muscle
• incipient to overt with or without heart failure and pulmonary congestion





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory