About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stab2tm1.1Cger
targeted mutation 1.1, Cyrill Geraud
MGI:5000471
Summary 4 genotypes


Genotype
MGI:5000488
hm1
Allelic
Composition		 Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic
Background		 B6.129S2-Stab2tm1.1Cger
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stab2tm1.1Cger mutation (0 available); any Stab2 mutation (138 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:171818 )
• mice exhibit no physical or behavioral abnormalities




Genotype
MGI:5000487
hm2
Allelic
Composition		 Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic
Background		 C.129S2-Stab2tm1.1Cger
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stab2tm1.1Cger mutation (0 available); any Stab2 mutation (138 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:171818 )
• mice exhibit no physical or behavioral abnormalities




Genotype
MGI:5000485
cx3
Allelic
Composition		 Stab1tm1.1Cger/Stab1tm1.1Cger
Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic
Background		 B6.129S2-Stab2tm1.1Cger Stab1tm1.1Cger
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stab1tm1.1Cger mutation (0 available); any Stab1 mutation (124 available)
Stab2tm1.1Cger mutation (0 available); any Stab2 mutation (138 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Liver fibrosis in Stab1tm1.1Cger/Stab1tm1.1Cger Stab2tm1.1Cger/Stab2tm1.1Cger mice

mortality/aging
premature death ( J:171818 )
• mean survival is 415 days

renal/urinary system
albuminuria ( J:171818 )
• moderately elevated at 3 and 6 months
• highly elevated at 18 months
renal glomerulus fibrosis ( J:171818 )
• mice exhibit collagen deposits and glomerular fibrosis unlike wild-type mice
• however, fibrosis is rescued by transplanting kidney into wild-type mice
renal glomerulus hypertrophy ( J:171818 )
• at 18 months, renal glomeruli are enlarged compared to in wild-type mice
abnormal kidney physiology ( J:171818 )
• albuminuria suggests impaired glomerular filter function compared to in wild-type mice

liver/biliary system
liver fibrosis ( J:171818 )
• perisinusoidal
abnormal liver physiology ( J:171818 )
• hepatic blood clearance of hyaluronan and Gdf15 is impaired compared to in wild-type mice

homeostasis/metabolism
albuminuria ( J:171818 )
• moderately elevated at 3 and 6 months
• highly elevated at 18 months

cardiovascular system
cardiovascular system phenotype ( J:171818 )
N
• mice do not exhibit signs of cardiac disease




Genotype
MGI:5000486
cx4
Allelic
Composition		 Stab1tm1.1Cger/Stab1tm1.1Cger
Stab2tm1.1Cger/Stab2tm1.1Cger
Genetic
Background		 C.129S2-Stab2tm1.1Cger Stab1tm1.1Cger
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stab1tm1.1Cger mutation (0 available); any Stab1 mutation (124 available)
Stab2tm1.1Cger mutation (0 available); any Stab2 mutation (138 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Mesangial expansion and glomerular fibrosis in Stab1tm1.1Cger/Stab1tm1.1CgerStab2tm1.1Cger/Stab2tm1.1Cger mice

mortality/aging
premature death ( J:171818 )
• mean survival is 269 days

cardiovascular system
dilated cardiomyopathy ( J:171818 )
• incipient to overt with or without heart failure and pulmonary congestion
congestive heart failure ( J:171818 )
• in some mice

renal/urinary system
albuminuria ( J:171818 )
• highly elevated at 3 and 6 months
renal glomerulus fibrosis ( J:171818 )
• mice exhibit collagen deposits and glomerular fibrosis unlike wild-type mice
• however, fibrosis is rescued by transplanting kidney into wild-type mice
abnormal kidney physiology ( J:171818 )
• albuminuria suggests impaired glomerular filter function compared to in wild-type mice

liver/biliary system
liver fibrosis ( J:171818 )
• perisinusoidal
abnormal liver physiology ( J:171818 )
• hepatic blood clearance of hyaluronan and Gdf15 is impaired compared to in wild-type mice

respiratory system

homeostasis/metabolism
albuminuria ( J:171818 )
• highly elevated at 3 and 6 months

muscle
dilated cardiomyopathy ( J:171818 )
• incipient to overt with or without heart failure and pulmonary congestion




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory