All Phenotypes Trp53<tm4Glo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53^tm4Glo
targeted mutation 4, Guillermina Lozano
MGI:5000493

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm4Glo/Trp53^tm4Glo	involves: 129S7/SvEvBrd * C57BL/6	MGI:5000507
ht2	Trp53^tm1Glo/Trp53^tm4Glo	involves: 129S7/SvEvBrd * C57BL/6	MGI:5000505
ht3	Trp53^tm3.1Glo/Trp53^tm4Glo	involves: 129S7/SvEvBrd * C57BL/6	MGI:5000508
cn4	Trp53^tm1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:5000506
cn5	Trp53^tm3.1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:5000509
cx6	Mdm4^tm3.1Glo/Mdm4^tm3.1Glo Trp53^tm4Glo/Trp53^tm4Glo	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5142304
cx7	Mdm2^tm1Glo/Mdm2^tm1Glo Trp53^tm1Glo/Trp53^tm4Glo	involves: 129S7/SvEvBrd * C57BL/6	MGI:5000502
cx8	Mdm2^tm1Glo/Mdm2^tm1Glo Trp53^tm3.1Glo/Trp53^tm4Glo	involves: 129S7/SvEvBrd * C57BL/6	MGI:5000504

Allelic Composition	Trp53^tm4Glo/Trp53^tm4Glo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm4Glo mutation (0 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:171821 )

• medial survival is 395 days due to tumor development

neoplasm

increased lymphoma incidence ( J:171821 )

• in 32% of mice (including T cell and diffuse)

increased T cell derived lymphoma incidence ( J:171821 )

increased adenocarcinoma incidence ( J:171821 )

• in 7% of mice

increased spindle cell carcinoma incidence ( J:171821 )

increased sarcoma incidence ( J:171821 )

• in 61% of mice (including angiosarcoma and spindle-cell)

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:171821 )

immune system

increased T cell derived lymphoma incidence ( J:171821 )

hematopoietic system

increased T cell derived lymphoma incidence ( J:171821 )

Allelic Composition	Trp53^tm1Glo/Trp53^tm4Glo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm1Glo mutation (0 available); any Trp53 mutation (240 available)
Trp53^tm4Glo mutation (0 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:171821 )

• medial survival is 251 days due to tumor development

neoplasm

abnormal tumor morphology ( J:171821 )

• tumors exhibit interstitial inflammatory cells unlike in tumors from Trp53^tm1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc mice

increased lipoma incidence ( J:171821 )

• in 2% of mice

increased lymphoma incidence ( J:171821 )

• in 34% of mice (including T cell, diffuse, anaplastic, and lymph node)

increased T cell derived lymphoma incidence ( J:171821 )

increased adenocarcinoma incidence ( J:171821 )

• in 2% of mice

increased spindle cell carcinoma incidence ( J:171821 )

increased sarcoma incidence ( J:171821 )

• in 61% of mice (including angiosarcoma, spindle-cell, giant-cell, and anaplastic)

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:171821 )

hematopoietic system

increased T cell derived lymphoma incidence ( J:171821 )

immune system

increased T cell derived lymphoma incidence ( J:171821 )

Allelic Composition	Trp53^tm3.1Glo/Trp53^tm4Glo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm3.1Glo mutation (0 available); any Trp53 mutation (240 available)
Trp53^tm4Glo mutation (0 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:171821 )

• median survival is 160 days due to tumor development

neoplasm

abnormal tumor morphology ( J:171821 )

• tumors exhibit interstitial inflammatory cells unlike in tumors from Trp53^tm3.1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc mice

increased lymphoma incidence ( J:171821 )

• in 60% of mice (including T cell, diffuse, and large cell)

increased adenocarcinoma incidence ( J:171821 )

• in 4% of mice

increased spindle cell carcinoma incidence ( J:171821 )

increased sarcoma incidence ( J:171821 )

• in 37% of mice (including angiosarcoma, spindle-cell, and giant-cell)

Allelic Composition	Trp53^tm1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
Trp53^tm1Glo mutation (0 available); any Trp53 mutation (240 available)
Trp53^tm4Glo mutation (0 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:171821 )

• tamoxifen-treated mice survive longer than Trp53^tm1Glo/Trp53^tm4Glo mice

neoplasm

abnormal tumor pathology ( J:171821 )

• tamoxifen-treated lymphomas exhibit decreased apoptosis response compared with tumors from Trp53^tm3.1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc mice

• tamoxifen-treated tumors exhibit decreased cell proliferation compared with control samples

• angiosarcomas treated with tamoxifen exhibit increased senescence compared with tamoxifen-treated angiosarcomas from Trp53^tm3.1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc mice

• tamoxifen-treatment induces apoptosis and senescence in giant-cell sarcoma

tumor regression ( J:171821 )

• in tamoxifen-treated mice

Allelic Composition	Trp53^tm3.1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
Trp53^tm3.1Glo mutation (0 available); any Trp53 mutation (240 available)
Trp53^tm4Glo mutation (0 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:171821 )

• tamoxifen-treated mice survive longer than Trp53^tm3.1Glo/Trp53^tm4Glo mice

neoplasm

abnormal tumor pathology ( J:171821 )

• tamoxifen-treated lymphomas exhibit increased apoptosis response compared with tumors from Trp53^tm1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc mice

• 3 of 5 tamoxifen-treated lymphomas exhibit senescence unlike in tumors from Trp53^tm1Glo/Trp53^tm4Glo Tg(CAG-cre/Esr1*)5Amc mice

• tamoxifen-treated angiosarcomas and lymphomas exhibit senescence

decreased tumor growth/size ( J:171821 )

• tamoxifen-treated mice exhibit little to no tumor growth unlike in control mice

Allelic Composition	Mdm4^tm3.1Glo/Mdm4^tm3.1Glo Trp53^tm4Glo/Trp53^tm4Glo
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm3.1Glo mutation (0 available); any Mdm4 mutation (193 available)
Trp53^tm4Glo mutation (0 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:174368 )

N	• unlike mice homozygous the Mdm4 allele alone, double mutant mice are viable

Allelic Composition	Mdm2^tm1Glo/Mdm2^tm1Glo Trp53^tm1Glo/Trp53^tm4Glo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Trp53^tm1Glo mutation (0 available); any Trp53 mutation (240 available)
Trp53^tm4Glo mutation (0 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:171821 )

growth/size/body

decreased body size ( J:171821 )

behavior/neurological

decreased locomotor activity ( J:171821 )

• less mobile

Allelic Composition	Mdm2^tm1Glo/Mdm2^tm1Glo Trp53^tm3.1Glo/Trp53^tm4Glo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Trp53^tm3.1Glo mutation (0 available); any Trp53 mutation (240 available)
Trp53^tm4Glo mutation (0 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:171821 )

N	• lethality observed in Mdm2^tm1Glo homozygotes is completely rescued with mice surviving beyond 5 weeks

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