Phenotypes associated with this allele

• Allele Symbol: Relb^shep
• Allele Name: spontaneous hepatitis
• Allele ID: MGI:5002714
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Relb^shep/Relb^shep	A;C-Relb^shep/GrsrJ	MGI:5003486

Genotype
MGI:5003486

hm1

• Allelic Composition: Relb^shep/Relb^shep
• Genetic Background: A;C-Relb^shep/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced body size in Relb^shep/Relb^shep mice

liver/biliary system

liver inflammation ( J:171971 )

• develops severe hepatitis with infiltration of mononuclear cells and fribrosis around portal areas

liver cirrhosis ( J:171971 )

pale liver ( J:171971 )

decreased liver function ( J:171971 )

liver failure ( J:171971 )

growth/size/body

decreased body size ( J:171971 )

• first detecable between 10 and 14 days of age and worsening with age compared with controls

decreased body weight ( J:171971 )

• approximately 65% smaller by weight by 20 days of age

limbs/digits/tail

thin tail ( J:171971 )

immune system

liver inflammation ( J:171971 )

• develops severe hepatitis with infiltration of mononuclear cells and fribrosis around portal areas

hematopoietic system

anemia ( J:171971 )

mortality/aging

lethality at weaning, complete penetrance ( J:171971 )

• while most homozygotes die by 3 weeks of age a few live to 4 weeks of age, but not beyond

preweaning lethality, incomplete penetrance ( J:171971 )

• fewer than the expected 25% homozygotes are produced from heterozygous intercrosses and most die by 3 weeks of age

homeostasis/metabolism

abnormal circulating protein level ( J:171971 )

• serum levels of albumin, amylase, and total protein are reduced

decreased circulating amylase level ( J:171971 )

decreased circulating serum albumin level ( J:171971 )

decreased circulating total protein level ( J:171971 )