Phenotypes associated with this allele

• Allele Symbol: Osr1^tm2Jian
• Allele Name: targeted mutation 2, Rulang Jiang
• Allele ID: MGI:5003109
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Osr1^tm2Jian/Osr1^tm2Jian Tg(Prrx1-cre)1Cjt/0	involves: 129S1/Sv * C57BL/6J * SJL/J	MGI:5003147
cn2	Osr1^tm2Jian/Osr1^tm2Jian Osr2^tm1Jian/Osr2^tm1Jian Tg(Prrx1-cre)1Cjt/0	involves: 129S1/Sv * C57BL/6J * SJL/J	MGI:5003149

Genotype
MGI:5003147

cn1

• Allelic Composition: Osr1^tm2Jian/Osr1^tm2Jian; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:171478 )

N • mice exhibit normal synovial joints

Genotype
MGI:5003149

cn2

• Allelic Composition: Osr1^tm2Jian/Osr1^tm2Jian; Osr2^tm1Jian/Osr2^tm1Jian; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL/J

skeleton

abnormal joint morphology ( J:171478 )

• mice exhibit disorganized interphalangeal and metacarpophalangeal joints compared with wild-type mice

• mice exhibit defects in joint cell differentiation compared to in wild-type mice

fused synovial joints ( J:171478 )

• wrist and ankle bones are abnormally shaped compared to in wild-type mice

• the humerus is fused to the ulna and radius unlike in wild-type mice

• the tibia is fused to the fibula at both the proximal and distal ends unlike in wild-type mice

• mice exhibit fusion of the intermediate cuneiform and navicular bones and fusion of the cuboidal and calcaneus bones unlike in wild-type mice

abnormal bone mineralization ( J:171478 )

• mice exhibit delayed bone mineralization of the digital bones compared with wild-type mice

vision/eye

failure of eyelid fusion ( J:171478 )