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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cul4atm1.2Pra
targeted mutation 1.2, Pradip Raychaudhuri
MGI:5003274
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cul4atm1.2Pra/Cul4atm1.2Pra Not Specified MGI:5003280


Genotype
MGI:5003280
hm1
Allelic
Composition
Cul4atm1.2Pra/Cul4atm1.2Pra
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4atm1.2Pra mutation (0 available); any Cul4a mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• multinucleated giant cells are detected unlike in Cul4atm1.1Pra homozygotes
• 9-fold increased compared with Cul4atm1.1Pra homozygotes
• very few sperm are motile unlike in Cul4atm1.1Pra homozygotes
• daily sperm production from spermatozoa is reduced compared to in Cul4atm1.1Pra homozygotes
• seminiferous tubules exhibit premature sloughing of germ cells compared to in Cul4atm1.1Pra homozygotes
• sperm tails exhibit cytoplasmic droplets unlike cells from Cul4atm1.1Pra homozygotes
• epididymal tubules lack sperm
• mice exhibit a deficiency in postmeitotic cells (round, elongated spermatids and sperm cells) compared with Cul4atm1.1Pra homozygotes
• the number of spermatozoa is decreased compared to in Cul4atm1.1Pra homozygotes
• sperm cells exhibit oval small heads, are headless, or are decapitated compared to in Cul4atm1.1Pra homozygotes
• the number of postmeitotic cells is decreased compared to in Cul4atm1.1Pra homozygotes
• meiosis is delayed compared to in cells from Cul4atm1.1Pra homozygotes
• however, mice exhibit normal synapsis of homologous chromosomes and formation of XY-body
• 2-fold
• female mice produce smaller litters than compared with Cul4atm1.1Pra homozygotes
• female mice produce smaller litters than wild-type mice
• male mice are unable to produce any offspring unlike Cul4atm1.1Pra homozygotes

cellular
• sperm tails exhibit cytoplasmic droplets unlike cells from Cul4atm1.1Pra homozygotes
• epididymal tubules lack sperm
• mice exhibit a deficiency in postmeitotic cells (round, elongated spermatids and sperm cells) compared with Cul4atm1.1Pra homozygotes
• the number of spermatozoa is decreased compared to in Cul4atm1.1Pra homozygotes
• sperm cells exhibit oval small heads, are headless, or are decapitated compared to in Cul4atm1.1Pra homozygotes
• multinucleated giant cells are detected unlike in Cul4atm1.1Pra homozygotes
• the number of postmeitotic cells is decreased compared to in Cul4atm1.1Pra homozygotes
• meiosis is delayed compared to in cells from Cul4atm1.1Pra homozygotes
• however, mice exhibit normal synapsis of homologous chromosomes and formation of XY-body
• 9-fold increased compared with Cul4atm1.1Pra homozygotes
• very few sperm are motile unlike in Cul4atm1.1Pra homozygotes
• pachytene spermatocytes exhibit impaired double-strand DNA repair compared with cell from Cul4atm1.1Pra homozygotes

homeostasis/metabolism
• pachytene spermatocytes exhibit impaired double-strand DNA repair compared with cell from Cul4atm1.1Pra homozygotes

endocrine/exocrine glands





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory