Phenotypes associated with this allele

• Allele Symbol: Tg(APOE-rtTA*M2,tetO-Rgs16)#Tmw
• Allele Name: transgene insertion, Thomas M Wilkie
• Allele ID: MGI:5004809
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(APOE-rtTA*M2,tetO-Rgs16)#Tmw/0	involves: C57BL/6 * DBA	MGI:5004844

Genotype
MGI:5004844

tg1

• Allelic Composition: Tg(APOE-rtTA*M2,tetO-Rgs16)#Tmw/0
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Fatty liver in doxycyline-treated Tg(APOE-rtTA*M2,tetO-Rgs16)#Tmw/0 mice

homeostasis/metabolism

decreased fatty acid oxidation ( J:172091 )

• low in doxycycline-treated mice fed a high-fat diet

decreased circulating glucose level ( J:172091 )

• in doxycycline-treated mice fed a high-fat diet

decreased circulating ketone body level ( J:172091 )

• in doxycycline-treated mice fed a high-fat diet

decreased circulating cholesterol level ( J:172091 )

• in doxycycline-treated mice fed standard chow, a high-fat diet, or a high-sucrose diet

increased circulating triglyceride level ( J:172091 )

• in doxycycline-treated mice fed a high-fat diet or a high-protein diet

increased liver triglyceride level ( J:172091 )

• in doxycycline-treated mice fed a high-fat diet or a high-protein diet

liver/biliary system

increased liver triglyceride level ( J:172091 )

• in doxycycline-treated mice fed a high-fat diet or a high-protein diet

hepatic steatosis ( J:172091 )

• on a high-fat, high-sucrose diet

cellular

decreased fatty acid oxidation ( J:172091 )

• low in doxycycline-treated mice fed a high-fat diet