Analysis Tools|
Allele Symbol Allele Name Allele ID |
Dppa3tm1(cre)Peli targeted mutation 1, Pentao Liu MGI:5004882 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• untreated mice show significantly increased mean spleen weight
• daily treatment with IGF1R kinase inhibitor NVP-AEW541 for 2 months restores spleen weight to wild-type levels
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• untreated mice show significantly increased mean spleen weight
• daily treatment with IGF1R kinase inhibitor NVP-AEW541 for 2 months restores spleen weight to wild-type levels
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• untreated mice show increased platelet number in peripheral blood
• daily treatment with IGF1R kinase inhibitor NVP-AEW541 for 1 or 2 months leads to a significant reduction in peripheral platelet number
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• untreated mice show increased leukocyte number in peripheral blood
• daily treatment with IGF1R kinase inhibitor NVP-AEW541 for 1 or 2 months leads to a significant reduction in peripheral leukocyte number
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• untreated mice show significantly increased % and absolute number of LSK+ cells in the bone marrow
• daily treatment with IGF1R kinase inhibitor NVP-AEW541 for 2 months restores % and absolute number of LSK+ cells in the bone marrow to wild-type levels
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• mice develop myeloproliferative neoplasm (MPN)-associated hematologic phenotypes
• daily treatment with IGF1R kinase inhibitor NVP-AEW541 ameliorates MPN-related phenotypes
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• mice exhibit a 50% reduction in ZFAND2B protein levels and a 2.2-fold increase in IGF1R (insulin-like growth factor I receptor) protein levels relative to wild-type controls
• Zfand2b mRNA levels are reduced in the bone marrow
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• untreated mice show significantly increased mean spleen weight
• daily treatment with IGF1R kinase inhibitor NVP-AEW541 for 2 months restores spleen weight to wild-type levels
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• untreated mice show increased leukocyte number in peripheral blood
• daily treatment with IGF1R kinase inhibitor NVP-AEW541 for 1 or 2 months leads to a significant reduction in peripheral leukocyte number
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/09/2024 MGI 6.24 |
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