Phenotypes associated with this allele

• Allele Symbol: Ptch1^wig
• Allele Name: wiggable
• Allele ID: MGI:5004953
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptch1^wig/Ptch1^wig	involves: 129S1/Sv * C57BL/6 * FVB/NJ	MGI:5006839

Genotype
MGI:5006839

hm1

• Allelic Composition: Ptch1^wig/Ptch1^wig
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Excessive leaf-like laminae or folia in the brain of E9.5-10.5 Ptch1^wig/Ptch1^wig embryos resembling a wig

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:171522 )

• embryos die by E11

growth/size/body

increased embryo size ( J:171522 )

• mutant embryos are visibly larger than controls

craniofacial

abnormal mandibular prominence morphology ( J:171522 )

• the mandibular prominence is massively overgrown

abnormal maxillary prominence morphology ( J:171522 )

• the maxillary prominence is massively overgrown and is is about twice the size of controls

abnormal nasal placode morphology ( J:171522 )

• the nasal placode is displaced and protrudes laterally

absent fourth pharyngeal arch ( J:171522 )

• agenesis of the fourth pharyngeal arch; a large cleft remained at the site where the third and fourth arches are normally located

small second pharyngeal arch ( J:171522 )

• the second pharyngeal arch is severely hypoplastic

absent third pharyngeal arch ( J:171522 )

• genesis of the third pharyngeal arch; a large cleft remained at the site where the third and fourth arches are normally located

hearing/vestibular/ear

small otic vesicle ( J:171522 )

• at E10.5, the otocysts are smaller than controls

nervous system

abnormal nervous system morphology ( J:171522 )

• at E10.5, mutants display hypoplasia of the peripheral nervous system including defects in cranial ganglia branching

abnormal neuron differentiation ( J:171522 )

• at E10.5, mutants display excessive neuronal differentiation in the hindbrain

abnormal neural plate morphology ( J:171522 )

• at E10.5, mutant embryos exhibit an excess of laminae or folia within the neural plate, particularly at the level of the forebrain, midbrain and anterior hindbrain

open neural tube ( J:171522 )

• at E10.5, the cranial neural folds are persistently open and have an everted and enlarged appearance

craniorachischisis ( J:171522 )

• rostral crainorachischesis

exencephaly ( J:171522 )

abnormal cranial ganglia morphology ( J:171522 )

• caudal to the otocyst, the cranial ganglia are hypoplastic or absent

• rudimentary condensations corresponding to the glossopharyngeal ganglion and the vagal ganglion may exist

abnormal vestibulocochlear ganglion morphology ( J:171522 )

• the facioacoustic/vestibulocochlear ganglion is abnormally shaped and persists as a round hypoplastic ganglia

abnormal geniculate ganglion morphology ( J:171522 )

• at E10.5, mutants display small facial ganglia and these are disconnected from the neural tube

abnormal glossopharyngeal ganglion morphology ( J:171522 )

• at E10.5, mutants display small glossopharyngeal ganglia and these are disconnected from the neural tube

abnormal trigeminal ganglion morphology ( J:171522 )

• at E9.5, trigeminal ganglion is missing the dorsal half, or proximal root, suggesting pertubations of neural crest cell migration in mutant embryos

• at E10.5, mutants display small trigeminal ganglia and these are disconnected from the neural tube

cardiovascular system

abnormal vascular development ( J:171522 )

• E9.5-10.5 wiggable embryos exhibit enhanced PECAM-1 staining compared to wild-type controls, indicative of a marked increase in endothelial cells and vasculature formation

taste/olfaction

abnormal nasal placode morphology ( J:171522 )

• the nasal placode is displaced and protrudes laterally

embryo

absent fourth pharyngeal arch ( J:171522 )

• agenesis of the fourth pharyngeal arch; a large cleft remained at the site where the third and fourth arches are normally located

small second pharyngeal arch ( J:171522 )

• the second pharyngeal arch is severely hypoplastic

absent third pharyngeal arch ( J:171522 )

• genesis of the third pharyngeal arch; a large cleft remained at the site where the third and fourth arches are normally located

increased embryo size ( J:171522 )

• mutant embryos are visibly larger than controls

abnormal neural plate morphology ( J:171522 )

• at E10.5, mutant embryos exhibit an excess of laminae or folia within the neural plate, particularly at the level of the forebrain, midbrain and anterior hindbrain

open neural tube ( J:171522 )

• at E10.5, the cranial neural folds are persistently open and have an everted and enlarged appearance

craniorachischisis ( J:171522 )

• rostral crainorachischesis

vision/eye

absent optic vesicle ( J:171522 )

• at E10.5, complete ocular agenesis is apparent, with absence of the optic vesicles; this phenotype may be secondary to the overgrowth of the maxillary prominence

respiratory system

abnormal nasal placode morphology ( J:171522 )

• the nasal placode is displaced and protrudes laterally

cellular

abnormal neuron differentiation ( J:171522 )

• at E10.5, mutants display excessive neuronal differentiation in the hindbrain