Phenotypes associated with this allele

• Allele Symbol: arco
• Allele Name: arco piccolo
• Allele ID: MGI:5004971
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	arco/arco	involves: 129S1/Sv * C57BL/6 * FVB/NJ	MGI:5006951

Genotype
MGI:5006951

hm1

• Allelic Composition: arco/arco
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small pharyngeal arch in E9.5-10.5 arco/arco embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:171522 )

• embryos die by E11

cardiovascular system

abnormal blood vessel morphology ( J:171522 )

• at E9.5-10.5, mutants display constricted capillaries or microvascular networks

abnormal pharyngeal arch artery morphology ( J:171522 )

• at E9.5-10.5, each of the pharyngeal arch arteries appear thinner or constricted

craniofacial

abnormal pharyngeal arch artery morphology ( J:171522 )

• at E9.5-10.5, each of the pharyngeal arch arteries appear thinner or constricted

small pharyngeal arch ( J:171522 )

• at E10.5, the pharyngeal arches are noticeably reduced in size compared to controls

small second pharyngeal arch ( J:171522 )

• at E9.5, severely hypoplastic second pharyngeal arch, which resembles the third arch in size

embryo

abnormal pharyngeal arch artery morphology ( J:171522 )

• at E9.5-10.5, each of the pharyngeal arch arteries appear thinner or constricted

small pharyngeal arch ( J:171522 )

• at E10.5, the pharyngeal arches are noticeably reduced in size compared to controls

small second pharyngeal arch ( J:171522 )

• at E9.5, severely hypoplastic second pharyngeal arch, which resembles the third arch in size

decreased embryo size ( J:171522 )

• at E9.5, mutant embryos are one half to two-thirds the size of control littermates

growth/size/body

decreased embryo size ( J:171522 )

• at E9.5, mutant embryos are one half to two-thirds the size of control littermates

nervous system

abnormal nervous system development ( J:171522 )

• at E10.5, mutants exhibit only rudimentary neuronal differentiation within the cranial ganglia and a complete lack of neuronal differentiation within the midbrain

abnormal cranial ganglia morphology ( J:171522 )

• at E10.5, ganglia appear reduced and axonal branching of the trigeminal and facial ganglia is lacking

abnormal glossopharyngeal ganglion morphology ( J:171522 )

• at E10.5, the glossopharyngeal ganglion is abnormally fused with the vagal and nerves from this combined ganglion project ectopically towards the facial ganglion

abnormal trigeminal ganglion morphology ( J:171522 )

• in E8.5-9.5 embryos, the trigeminal ganglion is abnormally shaped and the Sox10 positive neural crest cell population within the forming ganglion is disorganized and dispersed rather than forming a tight coalescence as it does in controls