Phenotypes associated with this allele

• Allele Symbol: Rhoa^tm1Yuyo
• Allele Name: targeted mutation 1, Yutaka Yoshida
• Allele ID: MGI:5004976
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rhoa^tm1Yuyo/Rhoa^tm1Yuyo Foxg1^tm1(cre)Skm/Foxg1^+	involves: 129P2/OlaHsd	MGI:5004979
cn2	Rhoa^tm1Yuyo/Rhoa^tm1Yuyo H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: C57BL/6J * CBA/J	MGI:5004977

Genotype
MGI:5004979

cn1

• Allelic Composition: Rhoa^tm1Yuyo/Rhoa^tm1Yuyo; Foxg1^tm1(cre)Skm/Foxg1⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain development ( J:172044 )

• the apical/ventricular surface is disorganized

exencephaly ( J:172044 )

• increasing incidence of exencephaly from E13.5 to E14.5

• exencephalic mass consists of greatly expanded neural progenitors

increased neuronal precursor cell number ( J:172044 )

• exencephalic mass consists of greatly expanded neural progenitors

Genotype
MGI:5004977

cn2

• Allelic Composition: Rhoa^tm1Yuyo/Rhoa^tm1Yuyo; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: C57BL/6J * CBA/J

nervous system

abnormal neuron proliferation ( J:172044 )

• accelerated proliferation and decreased cell cycle exit in neural progenitor cells in the midbrain

abnormal brain morphology ( J:172044 )

abnormal midbrain development ( J:172044 )

• around E11.5 multiple nodules are detected protruding from the apical surface of the mesencephalon and this phenotype becomes more severe by E12.5

• the cellular organization in the ventricular zone of the mesencephalon becomes highly irregular by E12.5

• after E12.5 dysplasia is seen in all embryos and by E13.5 dysplasia expands throughout the mesencephalon

• expansion of neural progenitor cells in the developing mesencephalon

abnormal midbrain morphology ( J:172044 )

• protrusions consisting of neuronal mass originating from the midbrain are exposed dorsally and push into the forebrain ventrally

• expression analysis indicates disruption of adherens junctions at the ventricular surface at E12.5

increased midbrain size ( J:172044 )

• enlarged at E13.5

exencephaly ( J:172044 )

• display exencephaly-like protrusions at E15.5

increased neuronal precursor cell number ( J:172044 )

• expansion of neural progenitor cells in the developing mesencephalon

cellular

abnormal neuron proliferation ( J:172044 )

• accelerated proliferation and decreased cell cycle exit in neural progenitor cells in the midbrain