All Phenotypes Fasl<tm2.1Bksa> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fasl^tm2.1Bksa
targeted mutation 2.1, Bruce R Ksander
MGI:5006688

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fasl^tm2.1Bksa/Fasl^tm2.1Bksa	D2.129-Fasl^tm2.1Bksa	MGI:5006704
hm2	Fasl^tm2.1Bksa/Fasl^tm2.1Bksa	involves: 129 * C57BL/6	MGI:5006702
cx3	Fas^lpr/Fas^lpr Fasl^tm2.1Bksa/Fasl^tm2.1Bksa	involves: 129 * C57BL/6 * MRL/Mp	MGI:5006703

Allelic Composition	Fasl^tm2.1Bksa/Fasl^tm2.1Bksa
Genetic Background	D2.129-Fasl^tm2.1Bksa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fasl^tm2.1Bksa mutation (0 available); any Fasl mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:171440 )

N	• mice develop glaucoma as in DBA/2J control mice

retina ganglion cell degeneration ( J:171440 )

• at 12 months, mice exhibit premature retinal ganglion cell loss due to apoptosis compared with similarly treated wild-type mice

• at 12 months, mice exhibit retinal degeneration in all layers of the retina unlike in wild-type mice

abnormal retina nerve fiber layer morphology ( J:171440 )

• at 5 and 12 months, mice exhibit loss of retinal nerve fibers unlike wild-type mice

nervous system

retina ganglion cell degeneration ( J:171440 )

• at 12 months, mice exhibit premature retinal ganglion cell loss due to apoptosis compared with similarly treated wild-type mice

• at 12 months, mice exhibit retinal degeneration in all layers of the retina unlike in wild-type mice

Allelic Composition	Fasl^tm2.1Bksa/Fasl^tm2.1Bksa
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fasl^tm2.1Bksa mutation (0 available); any Fasl mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:171440 )

N	• untreated mice exhibit normal retina morphology

increased retina apoptosis ( J:171440 )

• TNFalpha-treated mice exhibit increased apoptosis in the retinal ganglion layer unlike similarly treated wild-type mice

decreased retina ganglion cell number ( J:171440 )

• in saline- or TNFalpha-treated mice

retina ganglion cell degeneration ( J:171440 )

• after 1 week, TNFalpha-treated mice exhibit premature retinal ganglion cell loss due to apoptosis compared with similarly treated wild-type mice

abnormal retina nerve fiber layer morphology ( J:171440 )

• after 1 week, TNFa-treated mice exhibit premature loss of retinal nerve fibers unlike similarly treated wild-type mice

nervous system

decreased retina ganglion cell number ( J:171440 )

• in saline- or TNFalpha-treated mice

retina ganglion cell degeneration ( J:171440 )

• after 1 week, TNFalpha-treated mice exhibit premature retinal ganglion cell loss due to apoptosis compared with similarly treated wild-type mice

cellular

increased retina apoptosis ( J:171440 )

• TNFalpha-treated mice exhibit increased apoptosis in the retinal ganglion layer unlike similarly treated wild-type mice

Allelic Composition	Fas^lpr/Fas^lpr Fasl^tm2.1Bksa/Fasl^tm2.1Bksa
Genetic Background	involves: 129 * C57BL/6 * MRL/Mp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^lpr mutation (39 available); any Fas mutation (82 available)
Fasl^tm2.1Bksa mutation (0 available); any Fasl mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:171440 )

N	• TNFalpha-treated mice do not exhibit a decrease in retinal nerve fibers like in similarly treated wild-type mice

abnormal retina ganglion cell morphology ( J:171440 )

• after 1 week, TNFalpha-treated mice fail to exhibit a decrease in retinal ganglion cells unlike in similarly treated wild-type mice

nervous system

abnormal retina ganglion cell morphology ( J:171440 )

• after 1 week, TNFalpha-treated mice fail to exhibit a decrease in retinal ganglion cells unlike in similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24