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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fasltm1.1Bksa
targeted mutation 1.1, Bruce R Ksander
MGI:5006689
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fasltm1.1Bksa/Fasltm1.1Bksa involves: 129 MGI:5006705


Genotype
MGI:5006705
hm1
Allelic
Composition		 Fasltm1.1Bksa/Fasltm1.1Bksa
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fasltm1.1Bksa mutation (0 available); any Fasl mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina ganglion cell morphology ( J:171440 )
• TNFalpha-treated mice fail to exhibit a decrease in retinal ganglion cells unlike in similarly treated wild-type mice

immune system
enlarged spleen ( J:171440 )
• more severe than in Faslgld homozygotes
increased spleen weight ( J:171440 )
• more severe than in Faslgld homozygotes
enlarged lymph nodes ( J:171440 )
• more severe than in Faslgld homozygotes

nervous system
abnormal retina ganglion cell morphology ( J:171440 )
• TNFalpha-treated mice fail to exhibit a decrease in retinal ganglion cells unlike in similarly treated wild-type mice

hematopoietic system
enlarged spleen ( J:171440 )
• more severe than in Faslgld homozygotes
increased spleen weight ( J:171440 )
• more severe than in Faslgld homozygotes

growth/size/body
enlarged spleen ( J:171440 )
• more severe than in Faslgld homozygotes
increased spleen weight ( J:171440 )
• more severe than in Faslgld homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory