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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd79am1Anu
mutation 1, The Australian National University
MGI:5006856
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd79am1Anu/Cd79am1Anu C57BL/6-Cd79am1Anu MGI:5009420
hm2
 		Cd79am1Anu/Cd79am1Anu involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd MGI:5006964
cx3
 		Cd79am1Anu/Cd79am1Anu
Rasgrp1m1Anu/Rasgrp1m1Anu 		involves: C57BL/6JSfdAnu * CBA/J MGI:5565190


Genotype
MGI:5009420
hm1
Allelic
Composition		 Cd79am1Anu/Cd79am1Anu
Genetic
Background		 C57BL/6-Cd79am1Anu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79am1Anu mutation (2 available); any Cd79a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent pre-B cells ( J:171924 )
• only 15% of mIgM-B220lo cells from bone marrow of mice homozygous for this mutation are positive for cytoplasmic immunoglobulin M heavy chain (c-mu), consistent with the cells' inability to assemble pre-B cell receptors (pre-BCR)

immune system
absent pre-B cells ( J:171924 )
• only 15% of mIgM-B220lo cells from bone marrow of mice homozygous for this mutation are positive for cytoplasmic immunoglobulin M heavy chain (c-mu), consistent with the cells' inability to assemble pre-B cell receptors (pre-BCR)




Genotype
MGI:5006964
hm2
Allelic
Composition		 Cd79am1Anu/Cd79am1Anu
Genetic
Background		 involves: C57BL/6JSfdAnu * C57BL/10Sg * C57BR/cd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79am1Anu mutation (2 available); any Cd79a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent pre-B cells ( J:104190 )
• absolutely no B cells or pre-B cells
decreased IgG level ( J:104190 )
• hypogammaglobulinemia

immune system
absent pre-B cells ( J:104190 )
• absolutely no B cells or pre-B cells
decreased IgG level ( J:104190 )
• hypogammaglobulinemia




Genotype
MGI:5565190
cx3
Allelic
Composition		 Cd79am1Anu/Cd79am1Anu
Rasgrp1m1Anu/Rasgrp1m1Anu
Genetic
Background		 involves: C57BL/6JSfdAnu * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79am1Anu mutation (2 available); any Cd79a mutation (24 available)
Rasgrp1m1Anu mutation (2 available); any Rasgrp1 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:207898 )
N
• profoundly suppressed accumulation of PD1+ Helios+ CD4+ T cells compared with Rasgrp1m1Anu homozygotes
• restored number of effector/memory and regulatory CD4+ T cells compared with Rasgrp1m1Anu homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory