Phenotypes associated with this allele

• Allele Symbol: Pak2^tm1Rjak
• Allele Name: targeted mutation 1, Rolf Jakobi
• Allele ID: MGI:5006977
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pak2^tm1Rjak/Pak2^tm1Rjak	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5006979

Genotype
MGI:5006979

hm1

• Allelic Composition: Pak2^tm1Rjak/Pak2^tm1Rjak
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Pak2^tm1Rjak/Pak2^tm1Rjak embryos are smaller and less developed

mortality/aging

preweaning lethality, complete penetrance ( J:171914 )

• mice start to die at E8.0 with none detected postnatally

embryo

embryonic growth retardation ( J:171914 )

• at E10.5

decreased embryo size ( J:171914 )

• at E10.5

open neural tube ( J:171914 )

• head folds are prominent at E8.0

impaired somite development ( J:171914 )

• very few somites are present at E8.0

growth/size/body

embryonic growth retardation ( J:171914 )

• at E10.5

decreased embryo size ( J:171914 )

• at E10.5

nervous system

open neural tube ( J:171914 )

• head folds are prominent at E8.0