Phenotypes associated with this allele

• Allele Symbol: Pak2^tm1.1Rjak
• Allele Name: targeted mutation 1.1, Rolf Jakobi
• Allele ID: MGI:5006978
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pak2^tm1.1Rjak/Pak2^tm1.1Rjak	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5006980

Genotype
MGI:5006980

hm1

• Allelic Composition: Pak2^tm1.1Rjak/Pak2^tm1.1Rjak
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell death ( J:171914 )

• mouse embryonic fibroblasts (MEFs) exhibit increased spontaneous cell death compared with wild-type cells

• cisplatin-treated MEFs exhibit nonapoptotic cell death unlike similarly treated wild-type cells which undergo apoptosis

• however, the level of cisplatin-induced cell death is normal

increased fibroblast proliferation ( J:171914 )

• in mouse embryonic fibroblasts