immune system
• moderate in aged mice
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• moderate in aged mice
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• increased CD44hiCD62Llo CD8+ and CD4+ T cells at 6 to 7 months of age
• spontaneous activation of peripheral CD4+ and CD8+ T cells
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• on in vitro restimulation of T cells
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• on in vitro restimulation of T cells
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• increased leukocyte infiltration with tissue necrosis in several organs including lung, liver and pancreas
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endocrine/exocrine glands
liver/biliary system
respiratory system
hematopoietic system
• moderate in aged mice
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• moderate in aged mice
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• increased CD44hiCD62Llo CD8+ and CD4+ T cells at 6 to 7 months of age
• spontaneous activation of peripheral CD4+ and CD8+ T cells
|