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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Vsirtm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5006997
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Vsirtm1Lex/Vsirtm1Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:5770297
cx2
Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 MGI:5770302
cx3
Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 MGI:5770303
cx4
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
involves: 129S5/SvEvBrd * C57BL/6 MGI:5770298
cx5
Cd274tm1Igu/Cd274tm1Igu
Vsirtm1Lex/Vsirtm1Lex
involves: 129S5/SvEvBrd * C57BL/6 MGI:5770301


Genotype
MGI:5770297
hm1
Allelic
Composition
Vsirtm1Lex/Vsirtm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsirtm1Lex mutation (2 available); any Vsir mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• moderate in aged mice
• moderate in aged mice
• increased CD44hiCD62Llo CD8+ and CD4+ T cells at 6 to 7 months of age
• spontaneous activation of peripheral CD4+ and CD8+ T cells
• on in vitro restimulation of T cells
• on in vitro restimulation of T cells
• increased leukocyte infiltration with tissue necrosis in several organs including lung, liver and pancreas

endocrine/exocrine glands

liver/biliary system

respiratory system

hematopoietic system
• moderate in aged mice
• moderate in aged mice
• increased CD44hiCD62Llo CD8+ and CD4+ T cells at 6 to 7 months of age
• spontaneous activation of peripheral CD4+ and CD8+ T cells




Genotype
MGI:5770302
cx2
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
Genetic
Background
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (97 available)
Vsirtm1Lex mutation (2 available); any Vsir mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice do not develop overt autoimmune disease
• moderate in aged mice
• moderate in aged mice
• increased CD44hiCD62Llo CD8+ and CD4+ T cells at 6 to 7 months of age
• spontaneous activation of peripheral CD4+ and CD8+ T cells
• on in vitro restimulation of T cells
• when T cells are challenged with antigen
• on in vitro restimulation of T cells
• on in vitro restimulation of T cells
• increased leukocyte infiltration with tissue necrosis in several organs including lung, liver and pancreas

endocrine/exocrine glands

liver/biliary system

respiratory system

hematopoietic system
• moderate in aged mice
• moderate in aged mice
• increased CD44hiCD62Llo CD8+ and CD4+ T cells at 6 to 7 months of age
• spontaneous activation of peripheral CD4+ and CD8+ T cells




Genotype
MGI:5770303
cx3
Allelic
Composition
Pdcd1tm1Hon/Pdcd1tm1Hon
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1tm1Hon mutation (6 available); any Pdcd1 mutation (97 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
Vsirtm1Lex mutation (2 available); any Vsir mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit accelerated onset and succumb to complete hindlimb paralysis faster than control mice




Genotype
MGI:5770298
cx4
Allelic
Composition
Vsirtm1Lex/Vsirtm1Lex
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
Vsirtm1Lex mutation (2 available); any Vsir mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit accelerated onset compared with control mice




Genotype
MGI:5770301
cx5
Allelic
Composition
Cd274tm1Igu/Cd274tm1Igu
Vsirtm1Lex/Vsirtm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd274tm1Igu mutation (0 available); any Cd274 mutation (70 available)
Vsirtm1Lex mutation (2 available); any Vsir mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• spontaneous activation of peripheral CD4+ and CD8+ T cells

immune system
• spontaneous activation of peripheral CD4+ and CD8+ T cells





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory