About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ace2tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007005
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ace2tm1Lex/Ace2tm1Lex B6;129S5-Ace2tm1Lex/Mmucd MGI:5828264
ot2
Ace2tm1Lex/Y B6;129S5-Ace2tm1Lex/Mmucd MGI:5828265


Genotype
MGI:5828264
hm1
Allelic
Composition
Ace2tm1Lex/Ace2tm1Lex
Genetic
Background
B6;129S5-Ace2tm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Lex mutation (2 available); any Ace2 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the coats the mutant mice were yellow-tinted when compared with controls

pigmentation
• the coats the mutant mice were yellow-tinted when compared with controls

respiratory system
• mice exposed to cigarette smoke for 3 weeks show a higher level of pulmonary inflammation, with increases in TGF-beta1, TNF-alpha, and IL-6, than exposed wild-type mice
• cigarette smoke exposed mice show an earlier airway epithelial thickening and more severe infiltration of white blood cells around the alveolus compared to exposed wild-type mice
• mice exposed to cigarette smoke for 3 weeks show a greater increase in resting respiratory rate than wild-type mice exposed to smoke

homeostasis/metabolism
• gelatinase activities, including MMP-2 and MMP-9, near the alveolus and bronchioles is continuously and more increased in cigarette exposed mutants than wild-type mice
• pulmonary ACE activity induced by cigarette smoke exposure is greater than in wild-type mice

immune system
• mice exposed to cigarette smoke for 3 weeks show a higher level of pulmonary inflammation, with increases in TGF-beta1, TNF-alpha, and IL-6, than exposed wild-type mice
• cigarette smoke exposed mice show an earlier airway epithelial thickening and more severe infiltration of white blood cells around the alveolus compared to exposed wild-type mice




Genotype
MGI:5828265
ot2
Allelic
Composition
Ace2tm1Lex/Y
Genetic
Background
B6;129S5-Ace2tm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Lex mutation (2 available); any Ace2 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the coats the mutant mice were yellow-tinted when compared with controls

pigmentation
• the coats the mutant mice were yellow-tinted when compared with controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory