integument
• the coats the mutant mice were yellow-tinted when compared with controls
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pigmentation
• the coats the mutant mice were yellow-tinted when compared with controls
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respiratory system
• mice exposed to cigarette smoke for 3 weeks show a higher level of pulmonary inflammation, with increases in TGF-beta1, TNF-alpha, and IL-6, than exposed wild-type mice
• cigarette smoke exposed mice show an earlier airway epithelial thickening and more severe infiltration of white blood cells around the alveolus compared to exposed wild-type mice
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• mice exposed to cigarette smoke for 3 weeks show a greater increase in resting respiratory rate than wild-type mice exposed to smoke
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homeostasis/metabolism
• gelatinase activities, including MMP-2 and MMP-9, near the alveolus and bronchioles is continuously and more increased in cigarette exposed mutants than wild-type mice
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• pulmonary ACE activity induced by cigarette smoke exposure is greater than in wild-type mice
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immune system
• mice exposed to cigarette smoke for 3 weeks show a higher level of pulmonary inflammation, with increases in TGF-beta1, TNF-alpha, and IL-6, than exposed wild-type mice
• cigarette smoke exposed mice show an earlier airway epithelial thickening and more severe infiltration of white blood cells around the alveolus compared to exposed wild-type mice
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