Phenotypes associated with this allele

• Allele Symbol: Acp1^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007006
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acp1^tm1Lex/Acp1^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5428928

Genotype
MGI:5428928

hm1

• Allelic Composition: Acp1^tm1Lex/Acp1^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased fibroblast proliferation ( J:171883 )

♀ • female mutant mice show an increased mean skin fibroblast proliferation rate

growth/size/body

decreased body size ( J:171883 )

♂ • male homozygous mutant mice were notably smaller than their gender-matched control littermates

immune system

increased interleukin-6 secretion ( J:171883 )

• homozygous mutant mice exhibit an increased mean serum IL-6 response to LPS challenge when compared with that of controls