Analysis Tools
hematopoietic system
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• mean platelet count is notably decreased
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skeleton
homeostasis/metabolism
| N |
• mice show normal jejunal expression of genes involved in acyl-CoA synthesis [including Acsl1, Acsl3, Slc27a2 (aka Fatp2), and Slc27a4 (aka Fatp4)] and no changes in dietary cholesterol absorption, plasma cholesterol levels, plasma triglycerides, or fasting plasma glucose levels relative to wild-type controls
• when fed a Western-type diet for 13 weeks, both males and females exhibit normal body weight gain relative to diet-matched wild-type controls
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• both male and female mice show a decrease of 60% in jejunal palmitoyl-CoA synthesis rate, indicating a substantial reduction in total jejunal LCFA acyl-CoA synthetase activity
• however, liver synthesis rate of palmitoyl-CoA is normal
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digestive/alimentary system
| N |
• mice show normal jejunal histology and no changes in jejunal expression of genes involved in fat absorption (including Dgat1, Mogat2, Mttp, Apob and Hnf4a)
• when overnight fasted mice are i.v. injected with the lipase inhibitor tyloxapol and then given a gastric bolus of olive oil supplemented with [3H]-radiolabeled oleic acid, both males and females show normal plasma radiotracer levels at 90 min post-gavage relative to wild-type controls, suggesting normal dietary long chain fatty acids (LCFA) absorption
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