Phenotypes associated with this allele

• Allele Symbol: C1qtnf1^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007035
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C1qtnf1^tm1Lex/C1qtnf1^tm1Lex	B6.129S5-C1qtnf1^tm1Lex	MGI:5902395

Genotype
MGI:5902395

hm1

• Allelic Composition: C1qtnf1^tm1Lex/C1qtnf1^tm1Lex
• Genetic Background: B6.129S5-C1qtnf1^tm1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:241403 )

N • mice fed a low-fat diet exhibit normal steady-state serum concentrations of cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol and beta-hydroxybutyrate

N • mice fed a high-fat diet exhibit normal body temperature, serum T3, T4, TSH, FGF-21, fasting glucose and fasting insulin levels, and glucose tolerance

decreased susceptibility to diet-induced obesity ( J:241403 )

♂ • in male mice fed a high-fat diet

increased circulating insulin level ( J:241403 )

♂ • in fasted male, but not female, mice fed a low-fat diet

impaired glucose tolerance ( J:241403 )

♂ • in male, but not female, fed a low-fat diet

insulin resistance ( J:241403 )

♂ • in male, but not female, fed a low-fat diet

abnormal lipid homeostasis ( J:241403 )

• male mice fed a low-fat diet exhibit enhanced lipid tolerance with increased triglyceride and non-esterified fatty acid clearance compared with wild-type mice

• a similar non-statistically significant affect was found in female mice fed a low-fat diet

• however, intestinal lipid absorption and liver triglyceride secretion are normal and mice fed a high-fat diet exhibit normal triglyceride and non-esterified fatty acid clearance

decreased circulating free fatty acids level ( J:241403 )

♂ • in male mice fed a high-fat diet

decreased circulating triglyceride level ( J:241403 )

♂ • in male mice fed a high-fat diet

decreased liver cholesterol level ( J:241403 )

♂ • in male fed a low- or high-fat diet

decreased liver triglyceride level ( J:241403 )

♂ • modestly in male mice fed a high-fat diet

increased liver triglyceride level ( J:241403 )

♂ • in male fed a low-fat diet

adipose tissue

decreased subcutaneous adipose tissue amount ( J:241403 )

♂ • in male mice fed a high-fat diet without a change in histology or increased infiltration of macrophage

♂ • however, epididymal fat deposits are normal when fed a high-fat diet

decreased body fat mass ( J:241403 )

♂ • in male mice fed a high-fat diet

decreased gonadal fat pad weight ( J:241403 )

♂ • in male, but not female, mice fed a low-fat diet

♂ • however, inguinal fat depot is the same as in wild-type mice when fed a low-fat diet

behavior/neurological

hyperactivity ( J:241403 )

♂ • in male mice fed a high-fat diet

growth/size/body

decreased body fat mass ( J:241403 )

♂ • in male mice fed a high-fat diet

decreased susceptibility to diet-induced obesity ( J:241403 )

♂ • in male mice fed a high-fat diet

integument

decreased subcutaneous adipose tissue amount ( J:241403 )

♂ • in male mice fed a high-fat diet without a change in histology or increased infiltration of macrophage

♂ • however, epididymal fat deposits are normal when fed a high-fat diet

liver/biliary system

decreased liver cholesterol level ( J:241403 )

♂ • in male fed a low- or high-fat diet

decreased liver triglyceride level ( J:241403 )

♂ • modestly in male mice fed a high-fat diet

increased liver triglyceride level ( J:241403 )

♂ • in male fed a low-fat diet

hepatic steatosis ( J:241403 )

♂ • in male fed a low-fat diet

♂ • however, mice fed a high-fat diet exhibit reduced liver steatosis compared with control mice