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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccbe1tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007046
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccbe1tm1Lex/Ccbe1tm1Lex involves: 129S5/SvEvBrd MGI:5432926


Genotype
MGI:5432926
hm1
Allelic
Composition		 Ccbe1tm1Lex/Ccbe1tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccbe1tm1Lex mutation (2 available); any Ccbe1 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
abnormal lymphangiogenesis ( J:186594 )
• mice lack lymph sacs with few Prox1+ and Lyve1+ lymphatic endothelial cells in the cardinal vein wall compared wild-type mice
• lymphatic endothelial cells fail to migrate unlike in wild-type mice

homeostasis/metabolism
edema ( J:186594 )
• from E13.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory