Phenotypes associated with this allele

• Allele Symbol: Cdhr5^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007056
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdhr5^tm1Lex/Cdhr5^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:6713510
cx2	Apc^tm1Cip/Apc^+ Cdhr5^tm1Lex/Cdhr5^tm1Lex	involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6	MGI:6713511

Genotype
MGI:6713510

hm1

• Allelic Composition: Cdhr5^tm1Lex/Cdhr5^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:301471 )

N • despite a slight increase in cellular proliferation, overall architecture of the intestinal mucosa appears intact

abnormal enterocyte proliferation ( J:301471 )

• mice exhibit a slight increase of cell proliferation in the intestinal epithelium

cellular

abnormal enterocyte proliferation ( J:301471 )

• mice exhibit a slight increase of cell proliferation in the intestinal epithelium

neoplasm

neoplasm ( J:301471 )

N • at ~20 months of age, homozygotes show no differences in lifespan or spontaneous tumor incidence relative to wild-type controls

Genotype
MGI:6713511

cx2

• Allelic Composition: Apc^tm1Cip/Apc⁺; Cdhr5^tm1Lex/Cdhr5^tm1Lex
• Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

digestive/alimentary system

increased intestinal adenoma incidence ( J:301471 )

• at 6-8 months of age, 83% of mice show symptoms of neoplasia (rectal bleeding, anemia, splenomegaly) and 1 or more macroadenomas in the intestinal tract relative to 56% in Apc^tm1Cip heterozygotes

• a greater % of mice develop 51 to 100 or over 100 polyps (all sizes) in the intestinal tract, and the average number of tumors per mouse is ~3-fold higher than that in Apc^tm1Cip heterozygotes

neoplasm

increased intestinal adenoma incidence ( J:301471 )

• at 6-8 months of age, 83% of mice show symptoms of neoplasia (rectal bleeding, anemia, splenomegaly) and 1 or more macroadenomas in the intestinal tract relative to 56% in Apc^tm1Cip heterozygotes

• a greater % of mice develop 51 to 100 or over 100 polyps (all sizes) in the intestinal tract, and the average number of tumors per mouse is ~3-fold higher than that in Apc^tm1Cip heterozygotes

increased tumor growth/size ( J:301471 )

• mice develop more tumors, esp. larger ones, in the intestinal tract; the average number of macroadenomas (>5 mm) per mouse is ~3-fold higher than that in Apc^tm1Cip heterozygotes

• however, no differences in tumor grade, aggressiveness or proliferation are observed