Phenotypes associated with this allele

• Allele Symbol: Cldn18^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007067
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cldn18^tm1Lex/Cldn18^tm1Lex	involves: 129S5/SvEvBrd	MGI:5487825

Genotype
MGI:5487825

hm1

• Allelic Composition: Cldn18^tm1Lex/Cldn18^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:195931 )

N • mice exhibit normal bone formation

abnormal osteoclast differentiation ( J:195931 )

• increased

increased osteoclast cell number ( J:195931 )

• in mice fed a normal or low calcium diet

decreased bone mineral content ( J:195931 )

• total body

decreased bone mineral density ( J:195931 )

• total body, vertebra and femur in mice fed a normal calcium diet

• exacerbated calcium deficiency-induced in mice fed a low calcium diet

decreased compact bone thickness ( J:195931 )

abnormal trabecular bone morphology ( J:195931 )

• increased trabecular separation at 26 weeks in mice fed a normal or low calcium diet

decreased trabecular bone volume ( J:195931 )

• in mice fed a normal calcium diet in mice fed a low calcium diet

• exacerbated calcium deficiency-induced

decreased bone trabecula number ( J:195931 )

• in mice fed a normal or low calcium diet

decreased trabecular bone connectivity density ( J:195931 )

decreased trabecular bone thickness ( J:195931 )

• in mice fed a normal or low calcium diet

decreased bone mass ( J:195931 )

• peak bone mass

increased bone resorption ( J:195931 )

• increased

decreased bone strength ( J:195931 )

• in mice fed a normal calcium diet

• exacerbated in mice fed a low calcium diet

endocrine/exocrine glands

abnormal gastric chief cell morphology ( J:195931 )

• decreased numbers of gastric chief cells

abnormal gastric parietal cell morphology ( J:195931 )

• decreased numbers of parietal cells

digestive/alimentary system

abnormal stomach mucosa morphology ( J:195931 )

• with marked inflammatory infiltrate and decreased numbers of gastric chief cells and parietal cells

abnormal gastric chief cell morphology ( J:195931 )

• decreased numbers of gastric chief cells

abnormal gastric parietal cell morphology ( J:195931 )

• decreased numbers of parietal cells

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:195931 )

N • mice exhibit normal levels of calcium, phosphate, glucose, albumin, creatinine and cholesterol

immune system

abnormal osteoclast differentiation ( J:195931 )

• increased

increased osteoclast cell number ( J:195931 )

• in mice fed a normal or low calcium diet

cellular

abnormal osteoclast differentiation ( J:195931 )

• increased

hematopoietic system

abnormal osteoclast differentiation ( J:195931 )

• increased

increased osteoclast cell number ( J:195931 )

• in mice fed a normal or low calcium diet