About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Crispld2tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007091
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Crispld2tm1Lex/Crispld2tm1Lex B6;129S5-Crispld2tm1Lex/Mmucd MGI:5828261


Genotype
MGI:5828261
hm1
Allelic
Composition		 Crispld2tm1Lex/Crispld2tm1Lex
Genetic
Background		 B6;129S5-Crispld2tm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crispld2tm1Lex mutation (2 available); any Crispld2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
improved glucose tolerance ( J:171883 )
• male homozygous mutant mice show enhanced glucose tolerance at all 3 time intervals tested

immune system
abnormal immune system morphology ( J:171883 )
• homozygous mutant mice exhibit numerous immunological abnormalities when compared with controls
abnormal immune system physiology ( J:171883 )
• homozygous mutant mice exhibit numerous immunological abnormalities when compared with controls

skeleton
abnormal skeleton morphology ( J:171883 )
• male homozygous mutant mice show notably decreased bone-related measurements when compared with controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory