Phenotypes associated with this allele

• Allele Symbol: Dhrs3^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007106
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dhrs3^tm1Lex/Dhrs3^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:5553308
hm2	Dhrs3^tm1Lex/Dhrs3^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5429610
ht3	Dhrs3^tm1Lex/Dhrs3^+	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5429611
cx4	Dhrs3^tm1Lex/Dhrs3^tm1Lex Tg(RARE-Hspa1b/lacZ)12Jrt/0	involves: 129S5/SvEvBrd * C57BL/6 * CD-1	MGI:5553307

Genotype
MGI:5553308

hm1

• Allelic Composition: Dhrs3^tm1Lex/Dhrs3^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:203823 )

• the few mice that are born die soon after birth

perinatal lethality, incomplete penetrance ( J:203823 )

• despite being present at close the Mendelian ratio at E14.5 and E17.5, fewer than expected mice are recovered at birth

skeleton

abnormal axial skeleton morphology ( J:203823 )

• at E14.5 and E17.5

micrognathia ( J:203823 )

vertebral fusion ( J:203823 )

• at E14.5 and E17.5

cervical vertebral fusion ( J:203823 )

• between the atlas and axis

delayed bone ossification ( J:203823 )

• at E14.5 and E17.5

cardiovascular system

abnormal heart morphology ( J:203823 )

• cardiac malformation in all mice at E14.5

double outlet right ventricle ( J:203823 )

• in 3 of 5 mice at E14.5

atrial septal defect ( J:203823 )

• in 3 of 5 mice at E14.5

abnormal interventricular septum morphology ( J:203823 )

• incomplete at E14.5

ventricular septal defect ( J:203823 )

• in 4 of 5 mice at E14.5

craniofacial

abnormal craniofacial morphology ( J:203823 )

• at E14.5 and E17.5

micrognathia ( J:203823 )

failure of palatal shelf elevation ( J:203823 )

• at E14.5

homeostasis/metabolism

abnormal retinol metabolism ( J:203823 )

• altered retinoid metabolism

• however, retinaldehyde levels are normal

growth/size/body

failure of palatal shelf elevation ( J:203823 )

• at E14.5

decreased birth body size ( J:203823 )

fetal growth retardation ( J:203823 )

• at E14.5

vision/eye

eyelids open at birth ( J:203823 )

behavior/neurological

absent gastric milk in neonates ( J:203823 )

digestive/alimentary system

failure of palatal shelf elevation ( J:203823 )

• at E14.5

Genotype
MGI:5429610

hm2

• Allelic Composition: Dhrs3^tm1Lex/Dhrs3^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

mortality/aging

preweaning lethality, complete penetrance ( J:171883 )

Genotype
MGI:5429611

ht3

• Allelic Composition: Dhrs3^tm1Lex/Dhrs3⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

nervous system

enhanced sensorimotor gating ( J:171883 )

• female heterozygous mice exhibited enhanced sensorimotor gating/attention during prepulse inhibition testing

Genotype
MGI:5553307

cx4

• Allelic Composition: Dhrs3^tm1Lex/Dhrs3^tm1Lex; Tg(RARE-Hspa1b/lacZ)12Jrt/0
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * CD-1

embryo

abnormal embryo development ( J:203823 )

• mice exhibit severe developmental abnormalities with increased in transgene activity