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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dolktm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007112
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dolktm1Lex/Dolktm1Lex B6;129S5-Dolktm1Lex/Mmucd MGI:5882210
ht2
 		Dolktm1Lex/Dolk+ B6;129S5-Dolktm1Lex/Mmucd MGI:5882211


Genotype
MGI:5882210
hm1
Allelic
Composition		 Dolktm1Lex/Dolktm1Lex
Genetic
Background		 B6;129S5-Dolktm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dolktm1Lex mutation (2 available); any Dolk mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:171883 )
• lethality of the homozygous null mutants is reported but stage is not specified




Genotype
MGI:5882211
ht2
Allelic
Composition		 Dolktm1Lex/Dolk+
Genetic
Background		 B6;129S5-Dolktm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dolktm1Lex mutation (2 available); any Dolk mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal depression-related behavior ( J:171883 )
• heterozygous mice show a decreased depressive-like response
abnormal response to novelty ( J:171883 )
• heterozygotes show an altered sensitivity to novelty-induced stress/anxiety
hyperalgesia ( J:171883 )
• heterozygotes show an increased sensitivity to tonic pain




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory