All Phenotypes Dpy19l2<tm1Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dpy19l2^tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007114

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dpy19l2^tm1Lex/Dpy19l2^tm1Lex	B6;129S5-Dpy19l2^tm1Lex/Mmucd	MGI:5438321

Allelic Composition	Dpy19l2^tm1Lex/Dpy19l2^tm1Lex
Genetic Background	B6;129S5-Dpy19l2^tm1Lex/Mmucd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dpy19l2^tm1Lex mutation (2 available); any Dpy19l2 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male germ cell morphology ( J:187630 )

• the nuclear dense lamina facing the acrosome is partially missing and the thickness of the acroplaxome-lamina area structure is irregular

abnormal sperm midpiece morphology ( J:187630 )

abnormal sperm mitochondrial sheath morphology ( J:187630 )

absent sperm mitochondrial sheath ( J:187630 )

abnormal sperm principal piece morphology ( J:187630 )

coiled sperm flagellum ( J:187630 )

multiflagellated sperm ( J:187630 )

abnormal acrosome morphology ( J:187630 )

• irregular and partially bound to unbound with numerous vacuoles

globozoospermia ( J:187630 )

detached acrosome ( J:187630 )

abnormal manchette morphology ( J:187630 )

• manchette develops but does not anchor to the right location and appears abnormally long

ectopic manchette ( J:187630 )

• mislocalized manchette

elongated manchette ( J:187630 )

abnormal seminiferous tubule morphology ( J:187630 )

small testis ( J:187630 )

decreased testis weight ( J:187630 )

abnormal sperm individualization ( J:187630 )

• incomplete individualization between spermatozoa in ~1% of sperm

male infertility ( J:187630 )

abnormal sperm physiology ( J:187630 )

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:187630 )

small testis ( J:187630 )

decreased testis weight ( J:187630 )

cellular

abnormal male germ cell morphology ( J:187630 )

• the nuclear dense lamina facing the acrosome is partially missing and the thickness of the acroplaxome-lamina area structure is irregular

abnormal sperm midpiece morphology ( J:187630 )

abnormal sperm mitochondrial sheath morphology ( J:187630 )

absent sperm mitochondrial sheath ( J:187630 )

abnormal sperm principal piece morphology ( J:187630 )

coiled sperm flagellum ( J:187630 )

multiflagellated sperm ( J:187630 )

abnormal acrosome morphology ( J:187630 )

• irregular and partially bound to unbound with numerous vacuoles

globozoospermia ( J:187630 )

detached acrosome ( J:187630 )

abnormal manchette morphology ( J:187630 )

• manchette develops but does not anchor to the right location and appears abnormally long

ectopic manchette ( J:187630 )

• mislocalized manchette

elongated manchette ( J:187630 )

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