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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dpy19l2tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007114
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dpy19l2tm1Lex/Dpy19l2tm1Lex B6;129S5-Dpy19l2tm1Lex/Mmucd MGI:5438321


Genotype
MGI:5438321
hm1
Allelic
Composition
Dpy19l2tm1Lex/Dpy19l2tm1Lex
Genetic
Background
B6;129S5-Dpy19l2tm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dpy19l2tm1Lex mutation (2 available); any Dpy19l2 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• the nuclear dense lamina facing the acrosome is partially missing and the thickness of the acroplaxome-lamina area structure is irregular
• irregular and partially bound to unbound with numerous vacuoles
• manchette develops but does not anchor to the right location and appears abnormally long
• mislocalized manchette
• incomplete individualization between spermatozoa in ~1% of sperm

endocrine/exocrine glands

cellular
• the nuclear dense lamina facing the acrosome is partially missing and the thickness of the acroplaxome-lamina area structure is irregular
• irregular and partially bound to unbound with numerous vacuoles
• manchette develops but does not anchor to the right location and appears abnormally long
• mislocalized manchette





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory