About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gfraltm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007153
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gfraltm1Lex/Gfraltm1Lex B6.129S5-Gfraltm1Lex MGI:6140072


Genotype
MGI:6140072
hm1
Allelic
Composition
Gfraltm1Lex/Gfraltm1Lex
Genetic
Background
B6.129S5-Gfraltm1Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfraltm1Lex mutation (2 available); any Gfral mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• no reduction in food intake when fed regular chow and administered Gdf15, whereas in wild-type mice intake reduces
• no reduction in food intake when fed regular chow and administered chemotherapeutic agent cisplatin, whereas in wild-type mice intake reduces
• when fed high-fat diet

growth/size/body
• no reduction in body weight when fed regular chow and administered Gdf15, whereas in wild-type mice weight reduces
• no reduction in body weight, adipose tissue, and fat and lean mass when fed regular chow and administered chemotherapeutic agent cisplatin, whereas in wild-type mice they reduce
• reduction in body weight when fed regular chow and administered Gcg (glucagon)
• gained more weight than wild-type mice when fed high-fat diet for 12 weeks: 32% greater total fat mass and 9% greater lean mass
• no weight gain differences with wild-type mice when fed regular chow

homeostasis/metabolism
N
• energy expenditure when fed regular chow
• gained more weight than wild-type mice when fed high-fat diet for 12 weeks: 32% greater total fat mass and 9% greater lean mass
• no weight gain differences with wild-type mice when fed regular chow
• no changes after 6 hours of fasting when fed high-fat diet, whereas in wild-type mice it does change
• when fed high-fat diet
• no changes after 6 hours of fasting when fed high-fat diet, whereas in wild-type mice it does change





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory