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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Glb1l2tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007155
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Glb1l2tm1Lex/Glb1l2tm1Lex B6;129S5-Glb1l2tm1Lex/Mmucd MGI:5829230


Genotype
MGI:5829230
hm1
Allelic
Composition		 Glb1l2tm1Lex/Glb1l2tm1Lex
Genetic
Background		 B6;129S5-Glb1l2tm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glb1l2tm1Lex mutation (2 available); any Glb1l2 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased leukocyte cell number ( J:171883 )
• homozygous mutant mice exhibit decreased mean white blood cell counts when compared with controls
decreased lymphocyte cell number ( J:171883 )
• homozygous mutant mice exhibit decreased lymphocyte counts when compared with controls
decreased NK cell number ( J:171883 )
• homozygous mutant mice exhibit decreased mean percentage of natural killer cells when compared with controls

homeostasis/metabolism
impaired glucose tolerance ( J:171883 )
• male mutant mice exhibit impaired glucose tolerance when compared with controls

immune system
decreased leukocyte cell number ( J:171883 )
• homozygous mutant mice exhibit decreased mean white blood cell counts when compared with controls
decreased lymphocyte cell number ( J:171883 )
• homozygous mutant mice exhibit decreased lymphocyte counts when compared with controls
decreased NK cell number ( J:171883 )
• homozygous mutant mice exhibit decreased mean percentage of natural killer cells when compared with controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory