All Phenotypes Gpc6<tm1Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gpc6^tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007162

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpc6^tm1Lex/Gpc6^tm1Lex	B6N.129S5(B6)-Gpc6^tm1Lex/Mmucd	MGI:6098734
cx2	Gpc6^tm1Lex/Gpc6⁺ Ihh^tm1Amc/Ihh⁺	involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6N	MGI:6098736
cx3	Gpc6^tm1Lex/Gpc6^tm1Lex Ihh^tm1Amc/Ihh^tm1Amc	involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6N	MGI:6098737

Allelic Composition	Gpc6^tm1Lex/Gpc6^tm1Lex
Genetic Background	B6N.129S5(B6)-Gpc6^tm1Lex/Mmucd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc6^tm1Lex mutation (3 available); any Gpc6 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:245694 )

skeleton

decreased chondrocyte proliferation ( J:245694 )

• in the growth plate

small cranium ( J:245694 )

abnormal long bone diaphysis morphology ( J:245694 )

• reduced length

abnormal long bone epiphyseal plate proliferative zone ( J:245694 )

• disorganized and lack the typical cell stacking in columns

decreased length of long bones ( J:245694 )

• at E17.5

short femur ( J:245694 )

• at E18.5, E17.5 and E15.5

short fibula ( J:245694 )

• at E18.5

short tibia ( J:245694 )

• at E18.5

craniofacial

small cranium ( J:245694 )

cleft palate ( J:245694 )

absent nasal septum ( J:245694 )

small snout ( J:245694 )

growth/size/body

cleft palate ( J:245694 )

absent nasal septum ( J:245694 )

small snout ( J:245694 )

decreased fetal weight ( J:245694 )

• at E17.5 to E18.5

cellular

decreased chondrocyte proliferation ( J:245694 )

• in the growth plate

digestive/alimentary system

cleft palate ( J:245694 )

respiratory system

absent nasal septum ( J:245694 )

limbs/digits/tail

short femur ( J:245694 )

• at E18.5, E17.5 and E15.5

short fibula ( J:245694 )

• at E18.5

short tibia ( J:245694 )

• at E18.5

Allelic Composition	Gpc6^tm1Lex/Gpc6⁺ Ihh^tm1Amc/Ihh⁺
Genetic Background	involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc6^tm1Lex mutation (3 available); any Gpc6 mutation (46 available)
Ihh^tm1Amc mutation (1 available); any Ihh mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased fetal weight ( J:245694 )

• unlike single heterozygotes at E17.5

limbs/digits/tail

short femur ( J:245694 )

• unlike single heterozygotes at E17.5

skeleton

short femur ( J:245694 )

• unlike single heterozygotes at E17.5

Allelic Composition	Gpc6^tm1Lex/Gpc6^tm1Lex Ihh^tm1Amc/Ihh^tm1Amc
Genetic Background	involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased fetal weight ( J:245694 )

• as in Ihh^tm1Amc homozygotes at E17.5

limbs/digits/tail

short femur ( J:245694 )

• as in Ihh^tm1Amc homozygotes at E17.5

skeleton

short femur ( J:245694 )

• as in Ihh^tm1Amc homozygotes at E17.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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