Phenotypes associated with this allele

• Allele Symbol: Gpr183^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007167
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr183^tm1Lex/Gpr183^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:5583966

Genotype
MGI:5583966

hm1

• Allelic Composition: Gpr183^tm1Lex/Gpr183^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating interferon-alpha level ( J:211122 )

• elevated interferon concentration measured in the peritoneal lavage fluid after intraperitoneal injections of the TLR7 agonist imiquimod compared to controls

• interferon levels were higher in mutant mice infected with virus at 3 days post-infection compared to controls

abnormal circulating interferon-beta level ( J:211122 )

• elevated interferon concentration measured in the peritoneal lavage fluid after intraperitoneal injections of the TLR7 agonist imiquimod compared to controls

increased circulating interferon-gamma level ( J:211122 )

immune system

decreased myeloid dendritic cell number ( J:211122 )

• myeloid dendritic cells in mutant spleens were reduced by approximately 60%

• in the peritoneum, the frequency of myeloid dendritic cells in the peritoneal lavage fluid is reduced by approximately 60% in mutant mice compared to littermate controls

• cell frequencies were normal in peripheral blood and no differences in overall total cell numbers in either spleen or peritoneal lavage fluid were observed

• B and T cell populations were found in normal numbers and frequencies

decreased plasmacytoid dendritic cell number ( J:211122 )

• plasmacytoid dendritic cells in mutant spleens were reduced by approximately 35%

• in the peritoneum, the frequency of plasmacytoid dendritic cells in the peritoneal lavage fluid is reduced by approximately 90% in mutant mice compared to littermate controls

• cell frequencies were normal in peripheral blood and no differences in overall total cell numbers in either spleen or peritoneal lavage fluid were observed

• B and T cell populations were found in normal numbers and frequencies

increased circulating interferon-alpha level ( J:211122 )

• elevated interferon concentration measured in the peritoneal lavage fluid after intraperitoneal injections of the TLR7 agonist imiquimod compared to controls

• interferon levels were higher in mutant mice infected with virus at 3 days post-infection compared to controls

abnormal circulating interferon-beta level ( J:211122 )

• elevated interferon concentration measured in the peritoneal lavage fluid after intraperitoneal injections of the TLR7 agonist imiquimod compared to controls

increased circulating interferon-gamma level ( J:211122 )

hematopoietic system

decreased myeloid dendritic cell number ( J:211122 )

• myeloid dendritic cells in mutant spleens were reduced by approximately 60%

• in the peritoneum, the frequency of myeloid dendritic cells in the peritoneal lavage fluid is reduced by approximately 60% in mutant mice compared to littermate controls

• cell frequencies were normal in peripheral blood and no differences in overall total cell numbers in either spleen or peritoneal lavage fluid were observed

• B and T cell populations were found in normal numbers and frequencies

decreased plasmacytoid dendritic cell number ( J:211122 )

• plasmacytoid dendritic cells in mutant spleens were reduced by approximately 35%

• in the peritoneum, the frequency of plasmacytoid dendritic cells in the peritoneal lavage fluid is reduced by approximately 90% in mutant mice compared to littermate controls

• cell frequencies were normal in peripheral blood and no differences in overall total cell numbers in either spleen or peritoneal lavage fluid were observed

• B and T cell populations were found in normal numbers and frequencies