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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hsd17b13tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007180
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hsd17b13tm1Lex/Hsd17b13tm1Lex B6;129S5-Hsd17b13tm1Lex/Mmucd MGI:5829222
hm2
 		Hsd17b13tm1Lex/Hsd17b13tm1Lex involves: 129S5/SvEvBrd * C57BL/6N MGI:7256401


Genotype
MGI:5829222
hm1
Allelic
Composition		 Hsd17b13tm1Lex/Hsd17b13tm1Lex
Genetic
Background		 B6;129S5-Hsd17b13tm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsd17b13tm1Lex mutation (2 available); any Hsd17b13 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:171883 )
• no notable phenotype was detected in a high-throughput phenotype screen of homozygous mice




Genotype
MGI:7256401
hm2
Allelic
Composition		 Hsd17b13tm1Lex/Hsd17b13tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsd17b13tm1Lex mutation (2 available); any Hsd17b13 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:273927 )
N
• mice exhibit normal fertility

liver/biliary system
increased liver triglyceride level ( J:273927 )
• in male mice at 9 months of age
liver inflammation ( J:273927 )
• portal inflammation and ductular proliferation in male mice by 3 months of age with microgranulomas
hepatic steatosis ( J:273927 )
• in male mice from 3 months of age with micro- and macrovesicular steatosis in most mice by 9 months of age
macrovesicular hepatic steatosis ( J:273927 )
• in most male mice by 9 months of age
microvesicular hepatic steatosis ( J:273927 )
• in most male mice by 9 months of age

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:273927 )
N
• male mice exhibit normal glucose tolerance and hepatic glucose output
decreased fatty acid beta-oxidation ( J:273927 )
• in hepatic mitochondria of male mice
increased liver triglyceride level ( J:273927 )
• in male mice at 9 months of age
increased lipogenesis ( J:273927 )
• increased hepatic de novo lipogenesis and fatty acid esterification as determined by gene expression analysis in male mice

immune system
liver inflammation ( J:273927 )
• portal inflammation and ductular proliferation in male mice by 3 months of age with microgranulomas

cellular
decreased fatty acid beta-oxidation ( J:273927 )
• in hepatic mitochondria of male mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory