behavior/neurological
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• male homozygous mutants show an increased anxiety-like response during stress-induced hyperthermia testing when compared with controls
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cellular
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• male homozygous mutant mice show decreased sperm production
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endocrine/exocrine glands
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• male homozygous mutant mice show vacuolar degeneration in the testes
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hematopoietic system
• homozygous mutant mice exhibited an increased mean serum IgG2a response to ovalbumin challenge
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homeostasis/metabolism
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• male homozygous mutants show an increased anxiety-like response during stress-induced hyperthermia testing when compared with controls
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immune system
• homozygous mutant mice exhibited an increased mean serum IgG2a response to ovalbumin challenge
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reproductive system
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• male homozygous mutant mice show decreased sperm production
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• male homozygous mutant mice show vacuolar degeneration in the testes
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• male homozygous mutant mice show infertility in the mutants
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