Phenotypes associated with this allele

• Allele Symbol: Nrros^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007223
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrros^tm1Lex/Nrros^tm1Lex	B6.129S5-Nrros^tm1Lex	MGI:6144085
cx2	Cybb^tm1Din/Cybb^tm1Din Nrros^tm1Lex/Nrros^tm1Lex	B6.129S-Nrros^tm1Lex Cybb^tm1Din	MGI:6144086

Genotype
MGI:6144085

hm1

• Allelic Composition: Nrros^tm1Lex/Nrros^tm1Lex
• Genetic Background: B6.129S5-Nrros^tm1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

oxidative stress ( J:209569 )

• significantly augmented ROS production from primary bone marrow derived macrophages (BMDMs) upon zymosan stimulation after priming for 24 h with either gamma interferon or lipopolysaccharide (LPS)

• ROS production from primary BMDMs upon zymosan stimulation after priming for 24 h with combination of gamma interferon and LPS

• significantly augmented ROS production from primary BMDMs upon challenge with E. coli, S. typhimrium or heat-killed Listeria monocytogenes (HKLM)

• higher reactive oxygen species (ROS) production in spleens upon infection with L. monocytogenes

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:209569 )

• enhanced disease severity and high mortality in myelin oligodendrocyte glycoprotein (MOG)35-55-complete Freunds adjuvant (CFA)-induced EAE experiments

decreased susceptibility to infection ( J:209569 )

• most mice survive L. monocytogenes infection dose that is fatal to most wild-type mice

• significantly reduced L. monocytogenes burden in livers and spleens after infection

• highly bactericidal action of BMDMs and neutrophils after infection in vitro

• enhanced bactericidal action upon inoculation with live E. coli

• when treated with ROS scavengers before infection with L. monocytogenes

Genotype
MGI:6144086

cx2

• Allelic Composition: Cybb^tm1Din/Cybb^tm1Din; Nrros^tm1Lex/Nrros^tm1Lex
• Genetic Background: B6.129S-Nrros^tm1Lex Cybb^tm1Din

cellular

cellular phenotype ( J:209569 )

N • normal reactive oxygen species (ROS) production

immune system

immune system phenotype ( J:209569 )

N • normal susceptibility to, and bacterial burden in livers and spleens after, L. monocytogenes infection