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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mpzl2tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007250
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mpzl2tm1Lex/Mpzl2tm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:5429590


Genotype
MGI:5429590
hm1
Allelic
Composition		 Mpzl2tm1Lex/Mpzl2tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpzl2tm1Lex mutation (3 available); any Mpzl2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:171883 )
• decreased mean percentage of B cells in the peripheral blood
• slightly decreased percentage of CD21Hi/CD23med cells in spleen
increased CD8-positive, alpha-beta T cell number ( J:171883 )
• increased mean percentage of CD8 cells in peripheral blood

immune system
decreased B cell number ( J:171883 )
• decreased mean percentage of B cells in the peripheral blood
• slightly decreased percentage of CD21Hi/CD23med cells in spleen
increased CD8-positive, alpha-beta T cell number ( J:171883 )
• increased mean percentage of CD8 cells in peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory