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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pomgnt1tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007295
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pomgnt1tm1Lex/Pomgnt1tm1Lex B6;129S5-Pomgnt1tm1Lex/Mmucd MGI:5828825


Genotype
MGI:5828825
hm1
Allelic
Composition		 Pomgnt1tm1Lex/Pomgnt1tm1Lex
Genetic
Background		 B6;129S5-Pomgnt1tm1Lex/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomgnt1tm1Lex mutation (1 available); any Pomgnt1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina blood vessel pattern ( J:171883 )
• disorganized pattern observed in the homozygous mutant mice upon fundus examination
retina microaneurysm ( J:171883 )
• observed in the homozygous mutant mice upon fundus examination

homeostasis/metabolism
decreased circulating glucose level ( J:171883 )
• compared with controls

nervous system
abnormal brain development ( J:171883 )
• microscopic analysis revealed developmental malformation of the brain in the mutants

vision/eye
abnormal retina blood vessel pattern ( J:171883 )
• disorganized pattern observed in the homozygous mutant mice upon fundus examination
retina microaneurysm ( J:171883 )
• observed in the homozygous mutant mice upon fundus examination
retina degeneration ( J:171883 )
• peripheral retinal degeneeration observed in the homozygous mutant mice upon fundus examination




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory