Phenotypes associated with this allele

• Allele Symbol: Prss57^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007300
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prss57^tm1Lex/Prss57^tm1Lex	involves: 129S5/SvEvBrd	MGI:6514729

Genotype
MGI:6514729

hm1

• Allelic Composition: Prss57^tm1Lex/Prss57^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal mast cell physiology ( J:301479 )

• IgE- and IgG-stimulated vascular permeability in the skin are significantly decreased compared to wild-type controls

• transfer of arthritic serum fails to induce increased joint vascular leakage unlike in wild-type controls

• transfer of wild-type mast cells into homozygous null mice restores vascular leakage responses

hematopoietic system

abnormal mast cell physiology ( J:301479 )

• IgE- and IgG-stimulated vascular permeability in the skin are significantly decreased compared to wild-type controls

• transfer of arthritic serum fails to induce increased joint vascular leakage unlike in wild-type controls

• transfer of wild-type mast cells into homozygous null mice restores vascular leakage responses