Phenotypes associated with this allele

• Allele Symbol: Slc39a14^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007337
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc39a14^tm1Lex/Slc39a14^tm1Lex	B6;129S5-Slc39a14^tm1Lex/Mmucd	MGI:6159105
hm2	Slc39a14^tm1Lex/Slc39a14^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5823427

Genotype
MGI:6159105

hm1

• Allelic Composition: Slc39a14^tm1Lex/Slc39a14^tm1Lex
• Genetic Background: B6;129S5-Slc39a14^tm1Lex/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:261326 )

N • mice exhibit normal calvarial bone thickness and porosity

Genotype
MGI:5823427

hm2

• Allelic Composition: Slc39a14^tm1Lex/Slc39a14^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

cellular

decreased hepatocyte proliferation ( J:236296 )

• at 24 hrs and 48 hrs after partial hepatectomy, hepatocyte proliferation is significantly lower than in similarly treated wild-type controls, as measured by CD1 and proliferating cell nuclear antigen (PCNA) expression and Ki67 staining

homeostasis/metabolism

increased circulating alanine transaminase level ( J:236296 )

• after partial hepatectomy, serum ALT levels are significantly higher than in similarly treated wild-type controls

abnormal liver zinc level ( J:236296 )

• after partial (70%) hepatectomy, mice fail to show a significant increase in total hepatic zinc levels, unlike similarly treated wild-type controls

• however, no differences in hepatic zinc levels are observed prior to hepatectomy

liver/biliary system

decreased hepatocyte proliferation ( J:236296 )

• at 24 hrs and 48 hrs after partial hepatectomy, hepatocyte proliferation is significantly lower than in similarly treated wild-type controls, as measured by CD1 and proliferating cell nuclear antigen (PCNA) expression and Ki67 staining

abnormal liver zinc level ( J:236296 )

• after partial (70%) hepatectomy, mice fail to show a significant increase in total hepatic zinc levels, unlike similarly treated wild-type controls

• however, no differences in hepatic zinc levels are observed prior to hepatectomy

decreased liver weight ( J:236296 )

• at 5 and 7 days after partial hepatectomy, mice have a significantly lower liver/body weight ratio than similarly treated wild-type controls

impaired liver regeneration ( J:236296 )

• mice display reduced hepatic zinc accumulation and hepatocyte proliferation in response to partial (70%) hepatectomy