Analysis Tools
adipose tissue
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• decreased intra-abdominal fat noted in 2 of 3 mutants during CAT-Scan
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• DEXA analysis reveals decreased total body fat in the male mutants
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behavior/neurological
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• female homozygous mutant mice exhibit increased locomotor activity during home cage activity testing
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• homozygous knockout mice exhibit higher activity during the dark phase (mouse subjective day) of the 12:12 L:D cycle in a home-cage environment, and the greater amount of locomotor activity during subjective day persisted into a D:D (24 hour dark cycle) challenge in females
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• total waking time of homozygous mice in the 12 hour dark phase was greater, to 125.6%, compared to those of WT littermates
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• NREM and REM sleep times were diminished, to 54.9% and 41.1%, respectively, compared to those of WT littermates
• knockout mice had significantly longer waking and shorter NREM times from the third through the seventh, and also the twelfth hour after the onset of darkness
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hematopoietic system
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• homozygous mutant mice exhibit an increased mean absolute monocyte count when compared with controls
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immune system
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• homozygous mutant mice exhibit an increased mean absolute monocyte count when compared with controls
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