About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxw7tm1Itom
targeted mutation 1, Ian Tomlinson
MGI:5007620
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fbxw7tm1Itom/Fbxw7+
Tg(Pgk1-cre)1Lni/0 		involves: 129 * BALB/c * C57BL/6 * C57BL/6J MGI:5007621


Genotype
MGI:5007621
cn1
Allelic
Composition		 Fbxw7tm1Itom/Fbxw7+
Tg(Pgk1-cre)1Lni/0
Genetic
Background		 involves: 129 * BALB/c * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Itom mutation (0 available); any Fbxw7 mutation (84 available)
Tg(Pgk1-cre)1Lni mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:172214 )
• all pups die shortly after birth

respiratory system
impaired lung alveolus development ( J:172214 )
• disruption of the canalicular and /or terminal sac stage of lung development
thick pulmonary interalveolar septum ( J:172214 )
• thickened alveolar septa at E18.5

vision/eye
eyelids open at birth ( J:172214 )
• in 17 of 40 mice

craniofacial
cleft palate ( J:172214 )
• in 30% of mice

digestive/alimentary system
cleft palate ( J:172214 )
• in 30% of mice

growth/size/body
cleft palate ( J:172214 )
• in 30% of mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory