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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Nr4a1-EGFP/cre)820Khog
transgene insertion 820, Kristin A Hogquist
MGI:5007644
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Cd4-BCL2*G101A*D102A*D103A)AWnt/0
Tg(Nr4a1-EGFP/cre)820Khog/0 		involves: C57BL/6 * C57BL/6J MGI:5661492
cx2
 		Tg(LCKprBCL2)36Sjk/0
Tg(Nr4a1-EGFP/cre)820Khog/0 		involves: C57BL/6 * C57BL/6J MGI:5661493
tg3
 		Tg(Nr4a1-EGFP/cre)820Khog/0 C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog MGI:5007650


Genotype
MGI:5661492
cx1
Allelic
Composition		 Tg(Cd4-BCL2*G101A*D102A*D103A)AWnt/0
Tg(Nr4a1-EGFP/cre)820Khog/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-BCL2*G101A*D102A*D103A)AWnt mutation (0 available)
Tg(Nr4a1-EGFP/cre)820Khog mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte apoptosis ( J:217939 )
• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death
abnormal T cell clonal deletion ( J:217939 )
• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death/clonal deletion

hematopoietic system
decreased thymocyte apoptosis ( J:217939 )
• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death
abnormal T cell clonal deletion ( J:217939 )
• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death/clonal deletion

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:217939 )
• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death

cellular
decreased thymocyte apoptosis ( J:217939 )
• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death




Genotype
MGI:5661493
cx2
Allelic
Composition		 Tg(LCKprBCL2)36Sjk/0
Tg(Nr4a1-EGFP/cre)820Khog/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(LCKprBCL2)36Sjk mutation (1 available)
Tg(Nr4a1-EGFP/cre)820Khog mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte apoptosis ( J:217939 )
• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death
abnormal T cell clonal deletion ( J:217939 )
• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death/clonal deletion

hematopoietic system
decreased thymocyte apoptosis ( J:217939 )
• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death
abnormal T cell clonal deletion ( J:217939 )
• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death/clonal deletion

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:217939 )
• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death

cellular
decreased thymocyte apoptosis ( J:217939 )
• mice exhibit a defect in thymocyte negative selection, showing an increase in the proportion of post-selection DP thymocytes which indicates rescue of these cells from death




Genotype
MGI:5007650
tg3
Allelic
Composition		 Tg(Nr4a1-EGFP/cre)820Khog/0
Genetic
Background		 C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nr4a1-EGFP/cre)820Khog mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:172415 )
N
• hemizygotes are viable and fertile with normal lymphoid and myeloid development

hematopoietic system
hematopoietic system phenotype ( J:172415 )
N
• hemizygotes are viable and fertile with normal lymphoid and myeloid development




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory