Phenotypes associated with this allele

• Allele Symbol: Apoe^tm4Mae
• Allele Name: targeted mutation 4, Nobuyo Maeda
• Allele ID: MGI:5007656
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apoe^tm4Mae/Apoe^tm4Mae	129S6/SvEvTac-Apoe^tm4Mae	MGI:5007659

Genotype
MGI:5007659

hm1

• Allelic Composition: Apoe^tm4Mae/Apoe^tm4Mae
• Genetic Background: 129S6/SvEvTac-Apoe^tm4Mae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating lipid level ( J:172417 )

• circulating lipid levels are twice as much as in Apoe^tm1Unc homozygotes

increased circulating cholesterol level ( J:172417 )

• 2.5 times higher than in Apoe^tm1Unc homozygotes

increased circulating HDL cholesterol level ( J:172417 )

• compared to in Apoe^tm1Unc homozygotes

increased circulating VLDL cholesterol level ( J:172417 )

• compared to in Apoe^tm1Unc homozygotes

increased circulating triglyceride level ( J:172417 )

• twice as much as in Apoe^tm1Unc homozygotes

growth/size/body

decreased body weight ( J:172417 )

• male mice exhibit reduced body weight compared Apoe^tm1Unc homozygous male mice

cardiovascular system

decreased susceptibility to atherosclerosis ( J:172417 )

• mice exhibit smaller atherosclerotic plaques in the aortic root area with increased latency compared to in Apoe^tm1Unc homozygotes

• mice form atherosclerotic plaques in the ascending aorta and aortic arch quicker than Apoe^tm1Unc homozygotes